Differential role of mucus plugs in asthma: Effects of smoking and association with airway inflammation
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- Oguma Akira
- Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University
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- Shimizu Kaoruko
- Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University
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- Kimura Hirokazu
- Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University
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- Tanabe Naoya
- Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University
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- Sato Susumu
- Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University
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- Yokota Isao
- Department of Biostatistics, Graduate School of Medicine, Hokkaido University
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- Takimoto-Sato Michiko
- Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University
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- Matsumoto-Sasaki Machiko
- Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University
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- Abe Yuki
- Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University
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- Takei Nozomu
- Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University
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- Goudarzi Houman
- Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University
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- Suzuki Masaru
- Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University
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- Makita Hironi
- Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University Hokkaido Medical Research Institute for Respiratory Diseases
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- Hirai Toyohiro
- Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University
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- Nishimura Masaharu
- Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University Hokkaido Medical Research Institute for Respiratory Diseases
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- Konno Satoshi
- Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University
抄録
<p>Background: The physiological importance of mucus plugs in computed tomography (CT) imaging is being increasingly recognized. However, whether airway inflammation and smoking affect the association between mucus plugs and clinical-physiological outcomes in asthma remains to be elucidated. The objective of this study is to examine how airway inflammation and/or smoking affect the correlation of CT-based mucus plug scores with exacerbation frequency and airflow limitation indices in asthma.</p><p>Methods: A total of 168 patients with asthma who underwent chest CT and sputum evaluation were enrolled and classified in eosinophilic asthma (EA; n = 103) and non-eosinophilic asthma (NEA; n = 65) groups based on sputum eosinophil percentage (cut-off: 3%). The mucus plug score was defined as the number of lung segments with mucus plugs seen on CT.</p><p>Results: More mucus plugs were detected on CT scans in the EA group than in the NEA group, regardless of smoking status. Mucus plug score and exacerbation frequency during one year after enrollment were significantly associated in the EA group but not in the NEA group after adjusting for demographics, blood eosinophil count, and fractional exhaled nitric oxide. Mucus plug score was associated with percentage of predicted forced expiratory volume in 1 s in non-smoking individuals in the EA and NEA group and in smoking individuals in the EA group but not in the NEA group after adjusting for demographics.</p><p>Conclusions: The association of mucus plug score with exacerbation frequency and reduced lung function may vary due to airway inflammatory profile and smoking status in asthma.</p>
収録刊行物
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- Allergology International
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Allergology International 72 (2), 262-270, 2023
一般社団法人日本アレルギー学会
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詳細情報 詳細情報について
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- CRID
- 1390577287341263232
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- ISSN
- 14401592
- 13238930
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可