Effects of vasoactive intestinal polypeptide (VIP) injection on plasma metabolic hormones in Holstein calves

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  • ホルスタイン種育成牛の血漿中代謝ホルモン濃度に及ぼす血管作動性腸管ポリペプチド(VIP) の影響

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Vasoactive intestinal polypeptide (VIP) is a gastrointestinal hormone isolated and discovered in pig blood vessels in 1902. However, few studies have investigated the effects of VIP administration on energy metabolism in the adrenocortical system, except in vitro. Therefore, in this study, we investigated the effect of VIP administration to calves on plasma glucose, NEFA, insulin, and cortisol concentrations. VIP administered 10 μg / kg BW to each calf via a jugular vein catheter. Plasma glucose and NEFA concentrations remained almost constant, and no significant difference was observed compared to the control group. The plasma insulin concentration was slightly higher than that of the control group from 15 to 30 minutes after administration, but no significant difference was observed. However, a significant increase in plasma cortisol concentration was observed at 10, 20 (P <0.01) and 30 (P <0.05) minutes after administration compared to the control group. An increase in cortisol concentration without changes in glucose and NEFA was observed, indicating that the energy metabolism of the adrenocortical pathway is not involved in the increase in blood glucose and NEFA concentration due to VIP administration.

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