Backstage of Neurodegenerative Disease Revealed by Nuclear Medicine Examinations

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  • Kobayashi Ryota
    Department of Psychiatry, Yamagata University School of Medicine.
  • Kawakatsu Shinobu
    Department of Neuropsychiatry, Aizu Medical Center, Fukushima Medical University
  • Morioka Daichi
    Department of Psychiatry, Yamagata University School of Medicine.
  • Sakamoto Kazutaka
    Department of Psychiatry, Yamagata University School of Medicine.
  • Hayashi Hiroshi
    Department of Occupational Therapy, Fukushima Medical University School of Health Sciences
  • Suzuki Akihito
    Department of Psychiatry, Yamagata University School of Medicine.

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  • 核医学検査で覗く変性疾患の楽屋裏

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Abstract

<p>  Nuclear medicine examinations are mainly classified into functional imaging and molecular imaging. Functional imaging includes cerebral perfusion scintigraphy, dopamine transporter imaging, and iodine-123-metaiodobenzylguanidine myocardial scintigraphy, while molecular imaging includes amyloid positron emission tomography (PET) and tau PET. In this report, focusing on functional imaging studies, we will explain how far the backstage (background pathology) of neurodegenerative diseases can be exposed by nuclear medicine examinations. First, regarding Alzheimerʼs disease (AD) , the usefulness of nuclear medicine examinations in atypical AD and suspected non-Alzheimerʼs disease pathophysiology, which presents with symptoms similar to AD, will be discussed. Next, for frontotemporal lobar degeneration, which has a more diverse backstage (background pathology) , how far backstage can be exposed using dopamine transporter imaging will be elucidated.</p>

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