Anti-MDA5 antibody-positive rapidly progressive interstitial lung disease after allogeneic hematopoietic cell transplantation successfully treated with triple immunosuppressive therapy
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- NAKAMURA Yuhei
- Division of Hematology, Jichi Medical University Saitama Medical Center
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- KAWAMURA Shunto
- Division of Hematology, Jichi Medical University Saitama Medical Center
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- MATSUMI Shimpei
- Division of Hematology, Jichi Medical University Saitama Medical Center
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- MATSUMOTO Kazuhisa
- Department of Respiratory Surgery, Kyoto University School of Medicine
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- TANAKA Satona
- Department of Respiratory Surgery, Kyoto University School of Medicine
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- ISHIKAWA Takuto
- Division of Hematology, Jichi Medical University Saitama Medical Center
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- MATSUOKA Akari
- Division of Hematology, Jichi Medical University Saitama Medical Center
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- MENO Tomohiro
- Division of Hematology, Jichi Medical University Saitama Medical Center
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- KAWAMURA Masakatsu
- Division of Hematology, Jichi Medical University Saitama Medical Center
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- TAKESHITA Junko
- Division of Hematology, Jichi Medical University Saitama Medical Center
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- YOSHINO Nozomu
- Division of Hematology, Jichi Medical University Saitama Medical Center
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- YOSHIMURA Kazuki
- Division of Hematology, Jichi Medical University Saitama Medical Center
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- MISAKI Yukiko
- Division of Hematology, Jichi Medical University Saitama Medical Center
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- GOMYO Ayumi
- Division of Hematology, Jichi Medical University Saitama Medical Center
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- OKADA Yosuke
- Division of Hematology, Jichi Medical University Saitama Medical Center
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- TAMAKI Masaharu
- Division of Hematology, Jichi Medical University Saitama Medical Center
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- KUSUDA Machiko
- Division of Hematology, Jichi Medical University Saitama Medical Center
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- AKAHOSHI Yu
- Division of Hematology, Jichi Medical University Saitama Medical Center
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- KAMEDA Kazuaki
- Division of Hematology, Jichi Medical University Saitama Medical Center
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- WADA Hidenori
- Division of Hematology, Jichi Medical University Saitama Medical Center
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- KIMURA Shun-ichi
- Division of Hematology, Jichi Medical University Saitama Medical Center
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- NAKASONE Hideki
- Division of Hematology, Jichi Medical University Saitama Medical Center
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- KAKO Shinichi
- Division of Hematology, Jichi Medical University Saitama Medical Center
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- DATE Hiroshi
- Department of Respiratory Surgery, Kyoto University School of Medicine
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- KANDA Yoshinobu
- Division of Hematology, Jichi Medical University Saitama Medical Center
Bibliographic Information
- Other Title
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- 同種造血幹細胞移植後の抗MDA5抗体陽性急速進行性間質性肺疾患に有効であった3剤併用免疫抑制療法
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Abstract
<p>A 34-year-old man with KMT2A-MLLT1 acute myeloid leukemia in first complete remission underwent allogeneic peripheral blood stem cell transplantation from his HLA-matched sister after conditioning with busulfan/cyclophosphamide. He did not have severe graft-versus-host disease, but he developed interstitial pneumonia six months after transplantation when his oral cyclosporine A (CsA) dose was reduced to 10 mg/day. He was given prednisolone (PSL), which temporarily improved his respiratory condition, but he quickly deteriorated when PSL was reduced. Anti-MDA5 antibody was found to be positive after additional testing, and a three-drug combination of intravenous cyclophosphamide+PSL+CsA was initiated for anti-MDA5 antibody positive rapidly progressive interstitial lung disease, which was effective for interstitial pneumonia. He received a successful living-donor lung transplant from his younger brother and sister. We present a case of rapidly progressive anti-MDA5 antibody positive interstitial lung disease in which the patient’s respiratory condition improved after triple therapy and subsequent living-donor lung transplantation.</p>
Journal
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- Rinsho Ketsueki
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Rinsho Ketsueki 64 (4), 250-254, 2023
The Japanese Society of Hematology