The ice-binding and cell-protection function of insect-derived antifreeze protein

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  • 昆虫由来不凍タンパク質の氷結晶結合機能と細胞保護機能
  • コンチュウ ユライ フトウタンパクシツ ノ コオリ ケッショウ ケツゴウ キノウ ト サイボウ ホゴ キノウ

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Some organisms can be alive in cold environment even below 0℃, in spite of the risk of freezing and hypothermia. How are these organisms able to maintain their life without freezing injury and cold damage? Antifreeze proteins (AFPs) are one of cryoprotective proteins found in various cold-adapted fish, insects, plants, and microorganisms living in cold environments. AFPs can bind to single ice crystal and inhibit its growth (ice-binding function). Moreover, AFPs can prolong the life-time of mammalian cells at low temperature through its binding to lipid bilayer (cell-protection function). Both functions of AFPs are thought to play important roles in sustaining the life of these organisms at low temperatures. In this paper, we introduce the ice-binding and cell-protection functions of insect-derived AFP.

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  • 低温科学

    低温科学 81 37-49, 2023-03-20

    低温科学第81巻編集委員会

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