Induction of hibernation and daily torpor of mammals in the laboratory

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  • 実験室における哺乳動物の冬眠・休眠誘導
  • ジッケンシツ ニ オケル ホニュウドウブツ ノ トウミン ・ キュウミン ユウドウ

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Abstract

Some mammals enter hibernation in winter and lower their body temperature to near ambient temperature. Mice and house musk shrews undergo daily torpor, in which they remain hypothermic for several hours. It is important to reproduce hibernation and daily torpor in the laboratory for elucidating their mechanisms. In the Syrian hamster, hibernation is induced under the condition of low ambient temperatures and long dark periods, and the essential time for hibernation induction varies depending on nutrient intake. Fasting and cold environment trigger the induction of daily torpor in mice and in shrews, respectively. Furthermore, rats, which are non-hibernators, can be induced to hibernation-like hypothermia with pharmacological methods. This article summarizes the induction of hibernation and torpor in the laboratory and discusses the prospects for hibernation research.

Journal

  • 低温科学

    低温科学 81 131-139, 2023-03-20

    低温科学第81巻編集委員会

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