Sex Differences in Long-Term Outcomes in Patients With Chronic Coronary Syndrome After Percutaneous Coronary Intervention　― Insights From a Japanese Real-World Database Using a Storage System ―

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  • Akashi Naoyuki
    Division of Cardiovascular Medicine, Jichi Medical University Saitama Medical Center
  • Matoba Tetsuya
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences
  • Kohro Takahide
    Department of Clinical Informatics, Jichi Medical University School of Medicine
  • Oba Yusuke
    Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine
  • Kabutoya Tomoyuki
    Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine
  • Imai Yasushi
    Division of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University
  • Kario Kazuomi
    Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine
  • Kiyosue Arihiro
    Department of Cardiovascular Medicine, The University of Tokyo Hospital
  • Mizuno Yoshiko
    Department of Cardiovascular Medicine, The University of Tokyo Hospital Development Bank of Japan
  • Nochioka Kotaro
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Clinical Research, Innovation, and Education Center, Tohoku University Hospital
  • Nakayama Masaharu
    Department of Medical Informatics, Tohoku University Graduate School of Medicine
  • Iwai Takamasa
    Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center
  • Miyamoto Yoshihiro
    Open Innovation Center, National Cerebral and Cardiovascular Center
  • Ishii Masanobu
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
  • Nakamura Taishi
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
  • Tsujita Kenichi
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
  • Sato Hisahiko
    Precision Inc.
  • Fujita Hideo
    Division of Cardiovascular Medicine, Jichi Medical University Saitama Medical Center
  • Nagai Ryozo
    Jichi Medical University School of Medicine
  • on behalf of the CLIDAS Research Group

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Description

<p>Background: Several studies have reported some sex differences in patients with coronary artery diseases. However, the results regarding long-term outcomes in patients with chronic coronary syndrome (CCS) are inconsistent. Therefore, the present study investigated sex differences in long-term outcomes in patients with CCS after percutaneous coronary intervention (PCI).</p><p>Methods and Results: This was a retrospective, multicenter cohort study. We enrolled patients with CCS who underwent PCI between April 2013 and March 2019 using the Clinical Deep Data Accumulation System (CLIDAS) database. The primary outcome was major adverse cardiovascular events (MACE), defined as a composite of cardiovascular death, non-fatal myocardial infarction, or hospitalization for heart failure. In all, 5,555 patients with CCS after PCI were included in the analysis (4,354 (78.4%) men, 1,201 (21.6%) women). The median follow-up duration was 917 days (interquartile range 312–1,508 days). The incidence of MACE was not significantly different between the 2 groups (hazard ratio [HR] 1.20; 95% confidential interval [CI] 0.97–1.47; log-rank P=0.087). After performing multivariable Cox regression analyses on 4 different models, there were still no differences in the incidence of MACE between women and men.</p><p>Conclusions: There were no significant sex differences in MACE in patients with CCS who underwent PCI and underwent multidisciplinary treatments.</p>

Journal

  • Circulation Journal

    Circulation Journal 87 (6), 775-782, 2023-05-25

    The Japanese Circulation Society

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