Moderate-to-vigorous Physical Activity and Sedentary Behavior Are Independently Associated With Renal Function: A Cross-sectional Study
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- Hara Megumi
- Department of Preventive Medicine, Faculty of Medicine, Saga University
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- Nishida Yuichiro
- Department of Preventive Medicine, Faculty of Medicine, Saga University
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- Tanaka Keitaro
- Department of Preventive Medicine, Faculty of Medicine, Saga University
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- Shimanoe Chisato
- Department of Preventive Medicine, Faculty of Medicine, Saga University Clinical Research Center, Saga University Hospital
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- Koga Kayoko
- Department of Preventive Medicine, Faculty of Medicine, Saga University
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- Furukawa Takuma
- Department of Preventive Medicine, Faculty of Medicine, Saga University
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- Higaki Yasuki
- Laboratory of Exercise Physiology, Faculty of Sports and Health Science, Fukuoka University
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- Shinchi Koichi
- Division of International Health and Nursing, Faculty of Medicine, Saga University
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- Ikezaki Hiroaki
- Department of Comprehensive General Internal Medicine, Kyushu University Graduate School of Medical Sciences Faculty of Medical Sciences
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- Murata Masayuki
- Department of General Internal Medicine, Kyushu University Hospital
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- Takeuchi Kenji
- Department of Preventive Medicine, Nagoya University Graduate School of Medicine
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- Tamura Takashi
- Department of Preventive Medicine, Nagoya University Graduate School of Medicine
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- Hishida Asahi
- Department of Preventive Medicine, Nagoya University Graduate School of Medicine
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- Tsukamoto Mineko
- Department of Preventive Medicine, Nagoya University Graduate School of Medicine
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- Kadomatsu Yuka
- Department of Preventive Medicine, Nagoya University Graduate School of Medicine
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- Matsuo Keitaro
- Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute Division of Cancer Epidemiology, Nagoya University Graduate School of Medicine
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- Oze Isao
- Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute
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- Mikami Haruo
- Cancer Prevention Center, Chiba Cancer Center Research Institute
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- Kusakabe Miho
- Cancer Prevention Center, Chiba Cancer Center Research Institute
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- Takezaki Toshiro
- Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences
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- Ibusuki Rie
- Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences
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- Suzuki Sadao
- Department of Public Health, Nagoya City University Graduate School of Medical Sciences
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- Nakagawa-Senda Hiroko
- Department of Public Health, Nagoya City University Graduate School of Medical Sciences
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- Matsui Daisuke
- Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine
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- Koyama Teruhide
- Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine
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- Kuriki Kiyonori
- Laboratory of Public Health, Division of Nutritional Sciences, School of Food and Nutritional Sciences, University of Shizuoka
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- Takashima Naoyuki
- Department of Public Health, Faculty of Medicine, Kindai University Department of Public Health, Shiga University of Medical Science
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- Nakamura Yasuyuki
- Department of Public Health, Shiga University of Medical Science Yamashina Racto Clinic and Medical Examination Center
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- Arisawa Kokichi
- Department of Preventive Medicine, Tokushima University Graduate School of Biomedical Sciences
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- Katsuura-Kamano Sakurako
- Department of Preventive Medicine, Tokushima University Graduate School of Biomedical Sciences
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- Wakai Kenji
- Department of Preventive Medicine, Nagoya University Graduate School of Medicine
抄録
<p>Background: Little is known about whether insufficient moderate-to-vigorous physical activity (MVPA) and longer sedentary behavior (SB) are independently associated with estimated glomerular filtration rate (eGFR) and chronic kidney disease (CKD), whether they interact with known risk factors for CKD, and the effect of replacing sedentary time with an equivalent duration of physical activity on kidney function.</p><p>Methods: We examined the cross-sectional association of MVPA and SB with eGFR and CKD in 66,603 Japanese cohort study in 14 areas from 2004 to 2013. MVPA and SB were estimated using a self-reported questionnaire, and CKD was defined as eGFR <60 mL/min/1.73 m2. Multiple linear regression analyses, logistic regression analyses, and an isotemporal substitution model were applied.</p><p>Results: After adjusting for potential confounders, higher MVPA and longer SB were independently associated with higher eGFR (P for trend MVPA <0.0001) and lower eGFR (P for trend SB <0.0001), and a lower odds ratio (OR) of CKD (adjusted OR of MVPA ≥20 MET·h/day, 0.76; 95% confidence interval [CI], 0.68–0.85 compared to MVPA <5 MET·h/day) and a higher OR of CKD (adjusted OR of SB ≥16 h/day, 1.81; 95% CI, 1.52–2.15 compared to SB <7 h/day), respectively. The negative association between MVPA and CKD was stronger in men, and significant interactions between sex and MVPA were detected. Replacing 1 hour of SB with 1 hour of physical activity was associated with about 3 to 4% lower OR of CKD.</p><p>Conclusion: These findings indicate that replacing SB with physical activity may benefit kidney function, especially in men, adding to the possible evidence on CKD prevention.</p>
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ｅｐｉｄｅｍｉｏｌｏｇｙ
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Ｊｏｕｒｎａｌ ｏｆ Ｅｐｉｄｅｍｉｏｌｏｇｙ 33 (6), 285-293, 2023-06-05
日本疫学会