DETECTION OF THE IRREGULAR ANTIBODIES IN PREGNANT WOMEN AND THE INCIDENCE OF HEMOLYTIC DISEASES AMONG FETUSES AND NEWBORNS IN OUR INSTITUTION AND THE RELATIONSHIP BETWEEN THE FREQUENCY OF PREGNANCY AND THE PROFILES OF ANTIBODIES

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  • Yokota Akiko
    Department of Clinical Laboratory, Yokohama Minami kyousai Hospital
  • Takanashi Joji
    Department of Clinical Laboratory, Yokohama Minami kyousai Hospital
  • Higa Seina
    Department of Clinical Laboratory, Yokohama Minami kyousai Hospital
  • Hara Yuko
    Department of Clinical Laboratory, Yokohama Minami kyousai Hospital
  • Nakayama Kazutaka
    Department of Hematology, Yokohama Minami kyousai Hospital
  • Sato Mayumi
    Department of Clinical Laboratory, Yokohama Minami kyousai Hospital
  • Tajika Kenji
    Department of Hematology, Yokohama Minami kyousai Hospital

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  • 当院における妊産婦の不規則抗体検出とHDFN発生状況，妊娠回数との関連性についての考察

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Abstract

<p>Blood type mismatch between the fetus and mother leads to allogeneic IgG-type antibody production by the mother. These maternal alloantibodies may cause hemolytic disease of the fetus and newborn (HDFN). To prevent HDFN, it is important to conduct antibody screening tests during pregnancy. We have conducted a total of 9,029 tests among 6,516 pregnant women in the last decade. Forty-seven Rh+ pregnant women were identified. Anti-E antibody was predominant (29.8%), followed by anti-Lea (23.4%) and anti-Jra (12.8%). Six patients had double antibodies, including three with anti-E+ c antibody. We examined 37 pregnant women to clarify the relationship between the history of pregnancies (number) and antibody production. Women with only 1 pregnancy had mainly the cold type antibodies and those against Lewis antigens (62.5%), showing low titers. Women with ≥2 pregnancies had antibodies against rhesus antigens (76.2%), with titers of more than 16-fold in 42.9% of cases. HDFN occurred in only one mother with anti-C+e. Just before her delivery, these antibodies could not be detected. Her baby, however, had HDFN which was caused by ABO mismatch. These findings confirmed the importance of the periodic implementation of antibody testing for pregnant women.</p>

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