A Case of Stage I Breast Cancer during the Lactation Period with High Preoperative Tumor Marker Levels

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  • TAKEMOTO Kana
    Breast Center, Ehime University Hospital Department of Hepato-Pancreato-Biliary and Breast Surgery, Ehime University Graduate School of Medicine
  • KAMEI Yoshiaki
    Breast Center, Ehime University Hospital Department of Hepato-Pancreato-Biliary and Breast Surgery, Ehime University Graduate School of Medicine
  • NISHIYAMA Kanako
    Breast Center, Ehime University Hospital Department of Hepato-Pancreato-Biliary and Breast Surgery, Ehime University Graduate School of Medicine
  • TAGUCHI Kana
    Breast Center, Ehime University Hospital Department of Hepato-Pancreato-Biliary and Breast Surgery, Ehime University Graduate School of Medicine
  • MURAKAMI Akari
    Breast Center, Ehime University Hospital Department of Hepato-Pancreato-Biliary and Breast Surgery, Ehime University Graduate School of Medicine
  • KITAZAWA Riko
    Division of Diagnostic Pathology, Ehime University Hospital
  • TAKADA Yasutugu
    Department of Hepato-Pancreato-Biliary and Breast Surgery, Ehime University Graduate School of Medicine

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  • 術前血清腫瘍マーカー高値を呈したStage I授乳期乳癌の1例

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Abstract

<p>A 35-year-old woman noted bloody discharge in her left nipple in the second month of the lactation. Three months later, a mass was observed in the left breast ; however, no hospital consults were carried out. During the eighth month of lactation, the persistence of the intermittent left nipple bloody discharge prompted a consult to our institution. She presented with a 70 mm mass around the A segment of her left breast. Mammography revealed a linear calcification in the segment, and contrast magnetic resonance imaging revealed segmentary non-mass enhancement. She was diagnosed with ductal carcinoma in situ in her left breast by core needle biopsy, with elevated levels of CEA and serum HER2. Positron emission tomography showed no apparent distant metastasis, lymph node metastasis, or tumor of other organs. Left mastectomy and sentinel lymph node biopsy were performed. The patient's high tumor marker levels were found to be due to breast cancer, which explained the rapid decrease of the tumor marker levels following the left breast mastectomy. The frequency of elevated tumor marker levels in early breast cancer is rare. In this case, we deduced that lactating breasts and extensive intraductal development contributed to elevated tumor marker levels.</p>

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