Investigation of load test method for micro-object using micro-scale constriction

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  • マイクロスケール狭窄部を利用した微小対象物への負荷試験方法の検討

Abstract

<p>It has been found that the viscoelasticity parameters of cells have a strong correlation with disease. Also, since individual cells have different characteristics, we would like to evaluate multiple cells simultaneously. We are currently developing a cell load test device using a channel with a micro-scale narrowed part.After optimizing the channel shape and materials, load tests on polystyrene particles and yeast were carried out. Finally, it was possible to carry out a stress test of more than 5 minutes on yeast with a diameter of less than 10 microns. In addition, we were able to observe the state of load application using the constriction. In the future, we will conduct a load test on red blood cells and white blood cells that are the same size as yeast, aiming for application to diagnosis.</p>

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