A Case of Pleomorphic Fibroma Mimicking Pleomorphic Lipoma

DOI
  • Shioiri Momoko
    Department of Dermatology, Kobe City Medical Center General Hospital
  • Fujii Yohsuke
    Department of Dermatology, Kobe City Medical Center General Hospital
  • Kitao Rikuma
    Department of Dermatology, Kobe City Medical Center General Hospital
  • Tai Yukimasa
    Department of Dermatology, Kobe City Medical Center General Hospital
  • Ogura Kanako
    Department of Dermatology, Kobe City Medical Center General Hospital
  • Nagano Tohru
    Department of Dermatology, Kobe City Medical Center General Hospital

Bibliographic Information

Other Title
  • Pleomorphic lipoma との鑑別に苦慮した Pleomorphic broma の 1 例

Abstract

<p>An 81-year-old woman presented with a tumor on her right lower abdomen, which rst appeared 3 years before. The tumor was asymptomatic ; however, it had been growing and changing to papillomatous appearance gradually. Histopathological testing revealed that it was composed of dense collagen bers with scattered atypical spindle-shaped cells, multinucleated giant cells, and mature adipocytes throughout dermis to subcutaneous tissue. CD34 and p16were positive in immunohistochemistry, and Ki-67 labeling rate was 10%. It had features of both pleomorphic lipoma and pleomorphic broma. Pleomorphic lipoma and pleomorphic broma are both benign neoplasms with good prognosis. Pleomorphic lipoma is classied as a soft tissue tumor, whereas pleomorphic broma is classied as a cutaneous tumor. Differentiation may be difcult because they express varied clinical and pathological patterns. Loss of RB1 gene, a tumor suppressor gene, has been identied recently in both pleomorphic lipoma and pleomorphic broma. We diagnosed the patient as pleomorphic broma. As variants between pleomorphic broma and pleomorphic lipoma may exist, further studies are needed. Skin Research, 22 : 109-113, 2023 </p>

Journal

  • Hifu no kagaku

    Hifu no kagaku 22 (2), 109-113, 2023

    Meeting of Osaka Dermatological Association/Meeting of Keiji Dermatological Association

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