Development of High-Speed Scanning Ion Conductance Microscopy for Super Resolution Topographic Imaging of Dynamic Structural Changes of Live Cells

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  • Honda Kota
    名古屋大学大学院工学研究科電子工学専攻
  • Ida Hiroki
    名古屋大学大学院工学研究科電子工学専攻
  • Takahashi Yasufumi
    名古屋大学大学院工学研究科電子工学専攻 金沢大学ナノ生命科学研究所

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Other Title
  • 超解像度ライブセルイメージングに資する高速走査型イオンコンダクタンス顕微鏡の発展
  • チョウカイゾウド ライブセルイメージング ニ シスル コウソク ソウサガタ イオンコンダクタンス ケンビキョウ ノ ハッテン

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Abstract

<p>Visualization of the dynamics on the living cell surface is essential for understanding cellular functions such as migration, cancer invasion, and differentiation. In order to evaluate cellular dynamics, it is necessary to develop visualization techniques with nanoscale spatial resolution and non-invasion. Scanning ion conductance microscopy (SICM) is one of the most powerful microscopy techniques for obtaining fragile cell morphology under physiological conditions. In recent years, several research groups have improved the temporal resolution of SICM to visualize rapid cellular reactions. Here, we provide an overview of SICM, including the basic scanning mode and equipment, and recent researches on the development of high-speed SICM.</p>

Journal

  • KENBIKYO

    KENBIKYO 58 (2), 71-75, 2023-08-30

    The Japanese Society of Microscopy

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