Clinicopathological Features and the Prevalence of Oxyntic Gland Neoplasm: A Single-center Retrospective Study
-
- Asahara Hikari
- Department of Gastroenterology, Kobe Red Cross Hospital, Japan
-
- Takao Toshitatsu
- Department of Gastroenterology, Kobe University Graduate School of Medicine, Japan
-
- Asahara Yumiko
- Asahara Clinic, Japan
-
- Asahara Masakyo
- Asahara Clinic, Japan
-
- Motomura Douglas
- Division of Gastroenterology, Department of Medicine, University of British Columbia, Canada
-
- Sakaguchi Hiroya
- Department of Gastroenterology, Kobe University Graduate School of Medicine, Japan
-
- Yoshizaki Tetsuya
- Department of Gastroenterology, Kobe University Graduate School of Medicine, Japan
-
- Ikezawa Nobuaki
- Department of Gastroenterology, Kobe University Graduate School of Medicine, Japan
-
- Takao Madoka
- Department of Gastroenterology, Kobe University Graduate School of Medicine, Japan
-
- Morita Yoshinori
- Department of Gastroenterology, Kobe University Graduate School of Medicine, Japan
-
- Toyonaga Takashi
- Department of Gastroenterology, Kobe University Graduate School of Medicine, Japan
-
- Komatsu Masato
- Division of Diagnostic Pathology, Kobe University Graduate School of Medicine, Japan
-
- Kushima Ryoji
- Department of Pathology, Shiga University of Medical Science Hospital, Japan
-
- Kodama Yuzo
- Department of Gastroenterology, Kobe University Graduate School of Medicine, Japan
抄録
<p>Objective We explored the clinicopathological characteristics and disease frequency of oxyntic gland neoplasms (OGNs). </p><p>Methods We retrospectively evaluated the data of patients pathologically diagnosed with OGN at an internal medicine clinic. </p><p>Patients A total of 13,240 upper gastrointestinal endoscopies were performed on 7,488 patients between December 1, 2017, and March 31, 2021. </p><p>Results We identified 27 patients with 30 histopathologically confirmed OGNs, yielding a disease frequency of 0.36% (27/7,488). Furthermore, multiple simultaneous lesions were found in 3 of 27 patients (11%). One (3.3%) of the 30 lesions was present in the antrum, whereas the remaining lesions occurred in the body of the stomach. Nine (33%) of the 27 patients had no history of Helicobacter pylori infection, whereas the remaining 18 (67%) were either currently or had been previously infected. Nevertheless, 27/30 lesions (90%) still occurred in non-atrophied regions. After endoscopic treatment, a histopathological examination of the resected specimens revealed submucosal infiltration in 8 (44%) of the 18 lesions; however, none of the lesions showed submucosal desmoplasia. For all patients with submucosal involvement, only observation was performed. There were no recurrent lesions found on follow-up. </p><p>Conclusion The period prevalence of OGN was 0.36%, which is much higher than previously reported. The discovery of a small submucosal appearing lesion with a faded yellow or white color and dilated microvasculature, especially in a non-atrophic area of the stomach, should raise suspicion for an OGN, which can be endoscopically managed. </p>
収録刊行物
-
- Internal Medicine
-
Internal Medicine 62 (19), 2763-2774, 2023-10-01
一般社団法人 日本内科学会