-
- TAKUBO Keiyo
- Department of Stem Cell Biology, National Center for Global Health and Medicine
Bibliographic Information
- Other Title
-
- 骨髄環境のイメージング
- コツズイ カンキョウ ノ イメージング
Search this article
Abstract
<p>Hematopoietic stem and progenitor cells in mammals primarily reside in the bone marrow after birth. There, the cellular dynamics and subsequent fate of those cells are regulated by the adjacent microenvironment, known as the niche, to sustain lifelong blood cell production. To analyze and study physiological hematopoiesis and various hematopoietic disorders, it is essential to deeply understand how the niche regulates hematopoiesis and how niche dysregulation occurs. However, the dynamics of hematopoietic stem and progenitor cells and their interactions with the niche are dynamic and complex, and our knowledge of the spatial organization of bone marrow cells and niche factors is still limited. In this review, I provide an overview of classical techniques for spatiotemporal understanding of the cellular communities in bone marrow, as well as recent advances in bone marrow imaging techniques and valuable animal models, and discuss future prospects in this field.</p>
Journal
-
- Rinsho Ketsueki
-
Rinsho Ketsueki 64 (9), 861-868, 2023
The Japanese Society of Hematology
- Tweet
Details 詳細情報について
-
- CRID
- 1390579156089815808
-
- NII Book ID
- AN00252940
-
- ISSN
- 18820824
- 04851439
-
- NDL BIB ID
- 033093569
-
- PubMed
- 37793859
-
- Text Lang
- ja
-
- Data Source
-
- JaLC
- NDL
- PubMed
-
- Abstract License Flag
- Disallowed