β-Carotene Protects Mice against Lipopolysaccharide and D-Galactosamine Induced Acute Liver Injury via Regulation of NF-κB, MAPK, and Nrf2 Signaling

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  • Wu Ting
    College of Life Sciences and Engineering, Foshan University
  • Xie Yueqing
    College of Life Sciences and Engineering, Foshan University
  • Wu Zhikai
    College of Life Sciences and Engineering, Foshan University
  • Li Yifei
    College of Life Sciences and Engineering, Foshan University
  • Jiang Mingzhen
    College of Life Sciences and Engineering, Foshan University
  • Yu Hongsen
    College of Life Sciences and Engineering, Foshan University
  • Li Xuhai
    College of Life Sciences and Engineering, Foshan University
  • Wang Jingjing
    College of Life Sciences and Engineering, Foshan University
  • Zhou Ershun
    College of Life Sciences and Engineering, Foshan University
  • Yang Zhengtao
    College of Life Sciences and Engineering, Foshan University

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<p>Acute liver injury (ALI), posing a serious threaten to our life, has emerged as a public health issue around the world. β-carotene has plenty of pharmacologic effects, such as anti-inflammatory, antioxidant, and antitumor activities. In this study, we focused on studying the protective role and potential molecular mechanisms of β-carotene against D-galactosamine (D-GalN) and lipopolysaccharide (LPS) induced ALI. Our results indicated that β-carotene pretreatment effectively hindered abnormal changes induced by LPS/D-GalN in liver histopathology. Meanwhile, serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were downgraded with β-carotene pretreatment. β-carotene pretreatment also decreased malondialdehyde content and myeloperoxidase activity, increased glutathione peroxidase and superoxide dismutase levels, and reduced the levels of tumor necrosis factor-a (TNF-α) and interleukin 6 (IL-6) in liver tissues. Further investigations found that β-carotene mediated multiple signaling pathways in LPS/D-GalN-induced ALI, inhibiting NF-κB and MAPK signaling and upregulating the expression of Nrf2 and HO-1 proteins. All findings indicate that β-carotene appears to protect mice against LPS/D-GalN induced ALI by reducing oxidative stress and inflammation, possibly via regulating NF-κB, MAPK, and Nrf2 signaling.</p>

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