Association between total fat and fatty acid intake and the risk of type 2 diabetes mellitus among Japanese adults: Analysis based on the JACC study
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- Yaegashi Akinori
- Department of Public Health, Graduate School of Medicine, Hokkaido University Department of Health and Nutrition, Faculty of Human Science, Hokkaido Bunkyo University
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- Kimura Takashi
- Department of Public Health, Faculty of Medicine, Hokkaido University
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- Wakai Kenji
- Department of Preventive Medicine, Nagoya University
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- Iso Hiroyasu
- National Center for Global Health and Medicine
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- Tamakoshi Akiko
- Department of Public Health, Faculty of Medicine, Hokkaido University
書誌事項
- タイトル別名
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- Associations of Total Fat and Fatty Acid Intake With the Risk of Type 2 Diabetes Mellitus Among Japanese Adults: Analysis Based on the JACC Study
抄録
<p>Background: We prospectively examined the associations of total fat and fatty acid intake with type 2 diabetes (T2D) among Japanese adults.</p><p>Methods: This study was conducted using data from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC). A validated food frequency questionnaire evaluated the intake of total fat and fatty acids. Diabetes was assessed using self-reported data. Multivariable logistic regression analysis was performed to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) of incident T2D across quintiles of total fat and fatty acid intake after adjusting for potential confounders.</p><p>Results: A total of 19,088 non-diabetic participants (age range, 40–79 years) enrolled in the JACC between 1988 and 1990 were included in this study. During the 5-year study period, 494 the participants developed T2D. The OR of T2D for the highest versus lowest quintiles was 0.58 (95% CI, 0.37–0.90) for total fat, 0.78 (95% CI, 0.51–1.20) for saturated fatty acid (SFA), 0.55 (95% CI, 0.35–0.86) for monounsaturated fatty acids (MUFA), 0.61 (95% CI, 0.39–0.96) for polyunsaturated fatty acids (PUFA), 0.64 (95% CI, 0.42–0.99) for n-3 PUFA, and 0.70 (95% CI, 0.45–1.09) for n-6 PUFA. Total fat and fatty acid (except SFA and n-6 PUFA) intake were inversely associated with T2D in men. Total fat and fatty acid intake were not associated with T2D in women.</p><p>Conclusion: Higher intakes of total fats, MUFA, PUFA, and n-3 PUFA were inversely associated with T2D among Japanese men.</p>
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ｅｐｉｄｅｍｉｏｌｏｇｙ
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Ｊｏｕｒｎａｌ ｏｆ Ｅｐｉｄｅｍｉｏｌｏｇｙ advpub (0), 2023
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