Insect growth-regulating activity of 1-benzyl-2-methylbenzimidazole derivatives on silkworms

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  • Henmi Shuhei
    Graduate School of Natural Science and Technology, Shimane University
  • Sueyoshi Ayumu
    Graduate School of Natural Science and Technology, Shimane University
  • Ono Hiroshi
    Research Center for Advanced Analysis, National Agriculture and Food Research Organization
  • Yamazaki Toshimasa
    Research Center for Advanced Analysis, National Agriculture and Food Research Organization
  • Inoue Konatsu
    Department of Life Science and Biotechnology, Faculty of Life and Environmental Science, Shimane University
  • Shiotsuki Takahiro
    Graduate School of Natural Science and Technology, Shimane University Department of Life Science and Biotechnology, Faculty of Life and Environmental Science, Shimane University

Abstract

<p>Derivatives of 1-benzyl-2-methylbenzimidazoles (BMBIs) were synthesized to evaluate their biological activities against Bombyx mori, a lepidopteran model insect. Synthesized BMBIs exhibited two different biological activities: inhibition of development and acute lethality. From a structural perspective, the activity varied with the position of the substitutions on the 1-benzyl moiety; BMBIs with substitutions on the 2 and/or 4 positions had comparatively high activity in comparison with those with substitutions on the 3-position. There was more activity for the inhibition of development with low doses, and more for acute lethality with high doses. The activity was also affected by the applied stage, that is, application in the 4th instar mostly interfered the larval molting or pupation, whereas that in the 3rd instar caused more acute mortality. Taken together, these results suggest that BMBIs have multiple modes of action.</p>

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