Pathological Complete Response after Beacon Regimen for Recurrent Colorectal Cancer of BRAF-Mutant—Report of a Case—
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- SUGENOYA Shinsuke
- Department of Surgery, Nagano Matsushiro General Hospital
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- NAKATA Takenari
- Department of Surgery, Nagano Matsushiro General Hospital
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- NAKAMURA Kenya
- Department of Surgery, Nagano Matsushiro General Hospital
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- WATANABE Takayuki
- Department of Surgery, Nagano Matsushiro General Hospital
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- OKITA Koichi
- Department of Surgery, Nagano Matsushiro General Hospital
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- KASUGA Yoshio
- Department of Surgery, Nagano Matsushiro General Hospital
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- UEHARA Go
- Department of Laboratory Medicine, Shinshu University School of Medicine
Bibliographic Information
- Other Title
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- BEACONレジメン施行後に病理学的CRを認めたBRAF変異再発横行結腸癌の1例
- BEACON レジメン シコウ ゴ ニ ビョウリガクテキ CR オ ミトメタ BRAF ヘンイ サイハツ オウコウ ケッチョウ ガン ノ 1レイ
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Abstract
<p>A 78-year-old woman underwent right hemicolectomy for cancer in the hepatic flexure of the transverse colon. Histologically, it was poorly differentiated adenocarcinoma, RAS mutation-negative, BRAF mutation-positive, and MSI-H. Since the resection margin was positive, mFOLFOX6 was performed from 4 weeks after the operation. After completion of 3 courses, a contrast-enhanced CT scan revealed a recurrence of 50 mm in size on the ventral side of the pancreatic head and 42 mm in size on the ventral side of the right greater psoas muscle, involving the ureter. He had a history of Basedow disease. Considering a risk of causing thyrotoxicosis as an immune-related adverse event of pembrolizumab, encorafenib + binimetinib + cetuximab therapy was started as second-line therapy. After 9 courses, the tumor disappeared leaving only a soft shadow, and a complete response was obtained on imaging. Meanwhile the regimen became unsustainable due to the infusion reaction. Since the curative resection was judged to be possible, pancreatoduodenectomy and right ureter combined resection and reconstruction were performed, and no tumor cells were found histopathologically. This is the first report in Japan of a complete pathological response to chemotherapy for BRAF-mutant colorectal cancer.</p>
Journal
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- Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)
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Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) 84 (5), 773-778, 2023
Japan Surgical Association
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Details 詳細情報について
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- CRID
- 1390579830877721984
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- NII Book ID
- AA11189709
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- ISSN
- 18825133
- 13452843
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- NDL BIB ID
- 032908330
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
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- Abstract License Flag
- Disallowed