Disruptive effect of impinging jet flow environment on the integrity of endothelial monolayer

DOI Web Site 被引用文献1件 参考文献23件 オープンアクセス
  • Sawasaki Kaoru
    Department of Mechanical Systems Engineering, Tokyo Metropolitan University
  • Nakamura Masanori
    Department of Electrical and Mechanical Engineering, Nagoya Institute of Technology
  • Imada Shuta
    Department of Electrical and Mechanical Engineering, Nagoya Institute of Technology
  • Horie Yuta
    Department of Mechanical Systems Engineering, Tokyo Metropolitan University
  • Takahashi Koji
    Department of Mechanical Systems Engineering, Tokyo Metropolitan University
  • Yamazaki Ruumi
    Department of Mechanical Systems Engineering, Tokyo Metropolitan University
  • Kimura Naoyuki
    Department of Cardiovascular Surgery, Saitama Medical Center, Jichi Medical University
  • Kawahito Koji
    Department of Cardiovascular Surgery, Jichi Medical University
  • Sakamoto Naoya
    Department of Mechanical Systems Engineering, Tokyo Metropolitan University Research Center for Medicine-Engineering Collaboration, Tokyo Metropolitan University

書誌事項

公開日
2023
DOI
  • 10.17106/jbr.37.130
公開者
特定非営利活動法人 日本バイオレオロジー学会

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説明

<p>Abnormal hemodynamic conditions caused by a blood jet flow impinging on the aortic wall have been considered to be involved in the pathogenesis of aortic disease. Aortic diseases are generally accompanied by dysfunction and damage of the endothelial cells (ECs) lining the inner surface of blood vessels; however, the details of the effect of impinging jet flow on ECs remain unclear. In the present study, we investigated the effect of impinging jet flow conditions on the integrity of an EC monolayer. Human aortic ECs were exposed to an impinging jet flow with a maximum wall shear stress (WSS) of 18.6 Pa for 2 h in a newly developed cylindrical T-shaped flow chamber. Consequently, the ECs were detached only in the region where the WSS and normal flow velocity immediately above the wall were high. Decreased expression of the intercellular junction molecule, PECAM-1, was also observed in this region. Multiple regression analysis revealed that EC density and PECAM-1 expression were significantly correlated with not only the WSS and WSS gradient but also the normal flow velocity. Our findings suggest that the distinctive mechanical environment under an impinging jet flow may disrupt endothelial integrity.</p>

収録刊行物

  • Journal of Biorheology

    Journal of Biorheology 37 (2), 130-137, 2023

    特定非営利活動法人 日本バイオレオロジー学会

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