Early recurrent hepatocellular carcinoma with portal vein tumor thrombosis successfully treated with rehepatectomy after multimodality treatment with lenvatinib and radiotherapy: A case report

Jin Yuta, Nishiyama Ryo, Koganei Yuta, Kimura Daiki, Aoyama Junya, Nakano Yutaka, Imai Shunichi, Shimogawara Tatsuya, Yamada Toru, Egawa Tomohisa

doi:10.2957/kanzo.64.641

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レンバチニブ及び放射線治療後の再肝切除による集学的治療が奏功した門脈腫瘍栓を伴う早期再発肝細胞癌の1例
レンバチニブオヨビホウシャセンチリョウゴノサイカンセツジョニヨルシュウガクテキチリョウガソウコウシタモンミャクシュヨウセンオトモナウソウキサイハツカンサイボウガンノ 1レイ

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Abstract

<p>A man in his 50s with hepatitis B was left untreated. Medical checkup revealed a hepatic mass that was diagnosed as hepatocellular carcinoma (HCC). S8 demonstrated two lesions, which underwent open anterior segmental resection of the liver. Histopathological diagnosis confirmed portal vein invasion (vp2). A computed tomography scan performed 2 months postoperation revealed portal vein tumor thrombosis (PVTT) in the left branch of the portal vein. The recurrence was considered high despite the possible rehepatectomy. Therefore, lenvatinib (LEN) administration was initiated and stereotactic radiotherapy was performed for PVTT; however, micrometastasis developed. A repeat liver resection was performed because PVTT and micrometastasis did not worsen under LEN administration. Thereafter, CyberKnife was performed for micrometastasis, which resulted in complete remission. Herein, we report a case that revealed the efficacy of multidisciplinary treatment, including LEN and radiation therapy, for HCC with recurring PVTT.</p>

Journal

Kanzo

Kanzo 64 (12), 641-648, 2023-12-01

The Japan Society of Hepatology

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