Effect of safinamide on morning-off phenomenon in elderly patients with Parkinson's disease

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  • Takizawa Shunya
    Emeritus Professor, Tokai University Head of Neurological Center, Kanagawa Rehabilitation Hospital
  • Kohara Saori
    Department of Clinical Technology, Tokai University Hospital
  • Sato Fumitomo
    Director of a Hospital, Atsugi Sato Hospital
  • Takahashi Wakoh
    Professor, Department of Neurology, Tokai University Oiso Hospital

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  • 高齢進行期パーキンソン病患者におけるサフィナミドのモーニングオフ改善効果

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Abstract

<p>Aim: Morning-off is a symptom experienced by patients with Parkinson's disease (PD), which markedly reduces patients' quality of life. The present study evaluated the effect of safinamide on morning-off in elderly PD patients.</p><p>Methods: This observational study included 30 PD patients treated with 50 or 100 mg/day of safinamide in the evening. Using patient-reported outcomes, we evaluated the effect of safinamide on daily/morning ON-time, daily/morning OFF-time, Unified Parkinson's Disease Rating Scale (UPDRS) Part III score, and non-motor symptoms. Data at baseline (treatment start) and at 4, 8, 12, and 16 weeks after baseline were recorded.</p><p>Results: The PD patients (75.8±7.5 years old) in this study, who tended to be older than in previous phase 2/3 or 3 studies, may represent real-world Japanese PD patients. Compared with baseline, safinamide significantly increased the daily ON-time at eight weeks and morning ON-time at four weeks. Safinamide significantly reduced the daily OFF-time and morning OFF-time at four weeks. The UPDRS Part III score was significantly reduced by 1 point at 12 weeks. Safinamide showed a tendency to reduce non-motor symptoms, such as anxiety, pain, and depressive feelings. There was no marked difference in these parameters between patients treated with 50 and 100 mg of safinamide.</p><p>Conclusions: Our results suggest that safinamide administered in the evening can benefit elderly patients who experience wearing off, especially morning off, and non-motor symptoms.</p>

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