<p>AIM: To elucidate health guidance methods for supporting clients’ self-care utilizing mobile phone applications (MPAs) within motivational specific health guidance (MSHG), focusing on workers who had undergone health guidance for the second consecutive year. The study explored the perspectives of health guidance providers and clients to achieve its objectives.</p><p>METHODS: 1) Health guidance providers: descriptions regarding “supporting self-care utilizing MPAs” were extracted from the health guidance records, questionnaires, and interview transcriptions. These descriptions were then categorized for analysis. 2) Clients: descriptions regarding “support for continued utilization of MPAs” and “challenges in maintaining MPAs usage” were extracted from the questionnaires and categorized for further analysis.</p><p>RESULTS: 1) “Support for self-care utilizing MPAs” was classified into nine categories, including factors such as “assessing clients’ familiarity with MPAs in advance” and “evaluating self-care following the previous year’s MSHG.” 2) “Supportive measures and challenges in sustaining MPAs usage” were classified into six categories, covering aspects such as “loss of opportunities or motivation for self-care utilizing MPAs” and “encouragement from peers through MPAs.</p><p>DISCUSSIONS: The process of health guidance is a collaborative effort between the providers and the clients to achieve a common goal. The health guidance methods should encompass several vital approaches such as respect for clients’ self-care experiences; enhancing learning MPAs in phases; evaluating MPAs’ functions based on client’s goal, information and communication technology literacy, and work environment; and leveraging the added value of MPAs.</p>