<i>Ex-vivo</i> 1.5T MR Imaging versus CT in Estimating the Size of the Pathologically Invasive Component of Lung Adenocarcinoma Spectrum Lesions
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- Yamada Daisuke
- Department of Radiology, St. Luke’s International University
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- Matsusako Masaki
- Department of Radiology, St. Luke’s International University
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- Yoneoka Daisuke
- Infectious Disease Surveillance Center, National Institute of Infectious Diseases
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- Oikado Katsunori
- Diagnostic Imaging Center, The Cancer Institute Hospital of Japanese Foundation for Cancer Research
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- Ninomiya Hironori
- Division of Pathology, The Cancer Institute Hospital of Japanese Foundation for Cancer Research
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- Nozaki Taiki
- Department of Radiology, St. Luke’s International University
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- Ishiyama Mitsutomi
- Diagnostic Imaging Center, The Cancer Institute Hospital of Japanese Foundation for Cancer Research
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- Makidono Akari
- Department of Diagnostic Radiology, Tokyo Metropolitan Children’s Medical Center
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- Otsuji Mizuto
- Department of Thoracic Surgery, Tokyo Metropolitan Bokutoh Hospital
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- Itoh Harumi
- Department of Radiology, Faculty of Medical Sciences, University of Fukui
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- Ojiri Hiroya
- Department of Radiology, The Jikei University School of Medicine and University Hospital
抄録
<p>Purpose: The purpose of this study was to investigate whether ex-vivo MRI enables accurate estimation of the invasive component of lung adenocarcinoma.</p><p>Methods: We retrospectively reviewed 32 patients with lung adenocarcinoma who underwent lung lobectomy. The specimens underwent MRI at 1.5T. The boundary between the lesion and the normal lung was evaluated on a 5-point scale in each three MRI sequences, and a one-way analysis of variance and post-hoc tests were performed. The invasive component size was measured histopathologically. The maximum diameter of each solid component measured on CT and MR T1-weighted (T1W) images and the maximum size obtained from histopathologic images were compared using the Wilcoxon signed-rank test. Inter-reader agreement was evaluated using intraclass correlation coefficients (ICC).</p><p>Results: T1W images were determined to be optimal for the delineation of the lesions (P < 0.001). The histopathologic invasive area corresponded to the area where the T1W ex-vivo MR image showed a high signal intensity that was almost equal to the intravascular blood signal. The maximum diameter of the solid component on CT was overestimated compared with the maximum invasive size on histopathology (mean, 153%; P < 0.05), while that on MRI was evaluated mostly accurately without overestimation (mean, 108%; P = 0.48). The interobserver reliability of the measurements using CT and MRI was good (ICC = 0.71 on CT, 0.74 on MRI).</p><p>Conclusion: Ex-vivo MRI was more accurate than conventional CT in delineating the invasive component of lung adenocarcinoma.</p>
収録刊行物
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- Magnetic Resonance in Medical Sciences
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Magnetic Resonance in Medical Sciences 23 (1), 92-101, 2024
日本磁気共鳴医学会