Repeated prophylactic treatment of a curcumin derivative CUD003 prevents lipopolysaccharide-induced depressive-like behavior by inhibiting excessive inflammation in mice.
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- Matsuzaki Hirokazu
- Lab. Pharmacol., Fac. Pharm. Sci., Josai Univ.
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- Yamamoto Yuta
- Lab. Pharmacol., Fac. Pharm. Sci., Josai Univ.
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- Nakajima Ryunosuke
- Lab. Pharmacol., Fac. Pharm. Sci., Josai Univ.
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- Ahn Shingi
- Lab. Pharmacol., Fac. Pharm. Sci., Josai Univ.
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- Sashida Masaki
- Lab. Pharmacol., Fac. Pharm. Sci., Josai Univ.
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- Meiyan Xuan
- Lab. Org. Med. Chem., Fac. Pharm. Sci., Josai Univ.
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- Takayama Jun
- Lab. Org. Med. Chem., Fac. Pharm. Sci., Josai Univ.
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- Sakamoto Takeshi
- Lab. Org. Med. Chem., Fac. Pharm. Sci., Josai Univ.
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- Bo Yuan
- Lab. Pharmacol., Fac. Pharm. Sci., Josai Univ.
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- Okazaki Mari
- Lab. Pharmacol., Fac. Pharm. Sci., Josai Univ.
Bibliographic Information
- Other Title
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- クルクミン誘導体CUD003の慢性前投与は過剰な炎症を抑制することによりLPS誘発抑うつ行動を予防する
Abstract
<p>Previously, we revealed that repeated prophylactic treatment with CUD003, a synthetic derivate of curcumin, suppressed the development of depressive-like behavior at lower doses than curcumin in a lipopolysaccharide (LPS)-induced depression model. In this study, we investigated the possible mechanism of the preventive effect of CUD003 on the LPS-induced depression-like behaviors in mice. Male BALB/c mice were orally pretreated with curcumin or CUD003 for 5 days before receiving single intraperitoneal injection of LPS (0.5 mg/kg). Plasma interleukin (IL)-1β and tumor necrosis factor (TNF)-α levels were assessed by enzyme-linked immunosorbent assay. Furthermore, reactive oxygen species (ROS) level in the hippocampal CA1 region was assessed by dihydroethidium staining. Twenty-four hours after LPS administration, IL-1β and TNF-α levels in plasma increased. In addition, enhanced oxidative stress with elevated level of ROS was detected in the hippocampus. Pretreatment with CUD003 (3 or 10 mg/kg) and 10 mg/kg curcumin but not 3 mg/kg curcumin suppressed all these changes. These results suggest that the mechanism of preventive effect of CUD003 on the LPS-induced depressive-like behavior in mice is related to suppression of inflammatory cytokines and reduction of oxidative stress.</p>
Journal
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- Proceedings for Annual Meeting of The Japanese Pharmacological Society
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Proceedings for Annual Meeting of The Japanese Pharmacological Society 97 (0), 1-B-P-045-, 2023
Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390580217715402624
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- ISSN
- 24354953
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
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- Abstract License Flag
- Disallowed