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- Terunuma Miho
- Niigata Univ., Grad. Sch. Med. and Dent. Sci., Div. Oral Biochem.
Bibliographic Information
- Other Title
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- アンモニアが関与する脳内老化システム
Abstract
<p>Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by cognitive decline and irreversible memory loss. Excessive amount of ammonia has been detected in the brain and serum of AD patients, and the toxicity of ammonia has been thought as a factor which contributes to the progression of AD. In the central nervous system, astrocytes play a key role in ammonia metabolism by expressing the enzyme called glutamine synthetase, which catalyzes the synthesis of glutamine from glutamate and ammonia, and supply glutamine to neurons for the production of neurotransmitters. Here we report that prolonged NH4Cl treatment accumulates amyloid precursor protein (APP) in astrocytes. Enhanced APP levels was detected in both the plasma membranes and intracellular compartments. Immunocytochemistry revealed that NH4Cl induces the accumulation of APP in the endoplasmic reticulum and cleaved to become amyloid beta. In addition, NH4Cl treatment induced astrocyte senescence, which inhibits cell proliferation. Together, our data suggests that ammonia induces the production and accumulation of APP and Aβ in astrocytes as well as astrocyte senescence, and possibly exacerbate AD pathology.</p>
Journal
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- Proceedings for Annual Meeting of The Japanese Pharmacological Society
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Proceedings for Annual Meeting of The Japanese Pharmacological Society 97 (0), 2-B-S33-3-, 2023
Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390580217715696896
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- ISSN
- 24354953
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
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- Abstract License Flag
- Disallowed