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- 黒澤 珠希
- 東京大・院農・獣医薬理 東京医科歯科大・院医歯・病態代謝解析学
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- 梶 典幸
- 麻布大・獣医・獣医学科・薬理学
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- 後藤 もも
- 東京大・院農・獣医薬理
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- 茶圓 貴志
- 東京大・院農・獣医薬理
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- 三原 大輝
- 東京大・院農・獣医薬理
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- 上住 円
- 九州大・生医研・細胞不均一性学
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- 吉本 由紀
- 東京医科歯科大・歯・分子発生学・口腔組織学分野
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- 湊 圭太郎
- 新潟大・院医歯・生体機能調節医学
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- 長谷 栄治
- 徳島大・研ポストLEDフォトニクス・医光融合研究部門
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- 大石 由美子
- 東京医科歯科大・院医歯・病態代謝解析学
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- 小池 博之
- 東京医科歯科大・院医歯・病態代謝解析学
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- 眞鍋 一郎
- 千葉大・院医・疾患システム医学
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- 上住 聡芳
- 九州大・生医研・細胞不均一性学
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- 堀 正敏
- 東京大・院農・獣医薬理
書誌事項
- タイトル別名
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- Organ Specificity of Mesenchymal Stromal Cells Underlie Homeostatic Tissue Maintenance of Multicellular Organisms.
抄録
<p>In biology, embryology has explained how multiple cell types arise from a fertilized egg and organs are formed. In the following chapter, we seek to explain the mechanisms of how organs from multiple cells are maintained in a homeostatic state. Understanding this state is essential for maintaining the health of us.</p><p>In general, organs consist of two major groups of cells: parenchymal cells and stromal cells. The properties of organs have been understood through the function of parenchymal cells. For example, hepatocytes are studied when investigating the function of the liver, and myocytes are studied as well. The interstitium, on the other hand, has been regarded as a scaffold for the parenchyma and as similar independent of organ origin. However, we focused on mesenchymal stromal cells (MSCs) for understanding organs.</p><p>In this study, we performed a comparative analysis of MSCs over six organs. We revealed the organ-specific character of MSCs and identified a muscle-maintaining functional molecule whose expression is reduced by aging. Its knockout mice exhibited a loss of muscle mass and muscle strength at a young age. The concept that MSCs maintain organ function, as demonstrated by this study, can be extended to other organs. In this presentation, we also would like to discuss the possibilities for future research development from a new perspective of 'understanding organs from the interstitium'.</p>
収録刊行物
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- 日本薬理学会年会要旨集
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日本薬理学会年会要旨集 97 (0), 3-B-O16-1-, 2023
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390580217715760256
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- ISSN
- 24354953
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
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- 抄録ライセンスフラグ
- 使用不可