Wheel-running-related dopamine release in the mouse nucleus accumbens

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  • Aoi Mori
    Dept. Pharmacol., Grad. Sch. Pharmaceut. Sci., Hokkaido Univ.
  • Arakaki Saya
    Dept. Pharmacol., Grad. Sch. Pharmaceut. Sci., Hokkaido Univ.
  • Minami Masahumi
    Dept. Pharmacol., Grad. Sch. Pharmaceut. Sci., Hokkaido Univ.

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Other Title
  • 輪回し行動に関連したマウス側坐核内ドパミン遊離

Abstract

<p>In this study, we examined wheel-running-related dopamine (DA) release in the mouse nucleus accumbens (NAc) to examine the potential of wheel-running behavior as a model of behavioral addiction in mice. Changes in the DA level were measured by a fiber photometry technique using GRAB_DA which enables high temporal resolution measurement of DA release. Male C57BL/6J mice were divided into three groups: when the partition separating the cage into two compartments was removed , group 1 was presented with a running wheel (RW), group 2 was presented with a fixed RW that could not be rotated, and group 3 was not presented with anything. DA levels in the NAc medial shell and NAc core were significantly elevated in groups 1 and 2 compared to group 3. Furthermore, DA levels in the NAc medial shell were significantly elevated in group 1 compared to group 2. On the other hand, there was no significant difference in DA levels in the NAc lateral shell among the three groups. These results suggest that DA release in the NAc medial shell may characterize the activity of the mesolimbic dopaminergic system during behavioral addictions. Further experiments including comparisons with other rewards, such as food and social interaction that do not induce behavioral addictions, are needed.</p>

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