Patient with cirrhosis with copper deficiency due to zinc preparation overdose: a case report
-
- Tadokoro Tomoko
- Department of Gastroenterology and Neurology, Kagawa University School of Medicine
-
- Oura Kyoko
- Department of Gastroenterology and Neurology, Kagawa University School of Medicine
-
- Takuma Kei
- Department of Gastroenterology and Neurology, Kagawa University School of Medicine
-
- Nakahara Mai
- Department of Gastroenterology and Neurology, Kagawa University School of Medicine
-
- Fujita Koji
- Department of Gastroenterology and Neurology, Kagawa University School of Medicine
-
- Mimura Shima
- Department of Gastroenterology and Neurology, Kagawa University School of Medicine
-
- Tani Joji
- Department of Gastroenterology and Neurology, Kagawa University School of Medicine
-
- Morishita Asahiro
- Department of Gastroenterology and Neurology, Kagawa University School of Medicine
-
- Ono Masafumi
- Department of Gastroenterology and Neurology, Kagawa University School of Medicine
-
- Himoto Takashi
- Department of Gastroenterology and Neurology, Kagawa University School of Medicine
-
- Masaki Tsutomu
- Department of Gastroenterology and Neurology, Kagawa University School of Medicine
Bibliographic Information
- Other Title
-
- 亜鉛製剤の長期投与中に急激な血球減少・末梢神経障害を生じた肝硬変患者の一例
- アエン セイザイ ノ チョウキ トウヨ チュウ ニ キュウゲキ ナ ケッキュウ ゲンショウ ・ マッショウ シンケイ ショウガイ オ ショウジタ カンコウヘン カンジャ ノ イチレイ
Search this article
Abstract
<p>A woman in her 50s underwent hepatectomy for type B cirrhosis and hepatocellular carcinoma. Approximately 15 months postoperatively, she developed anemia, decreased white blood cell count, and peripheral neuropathy. Her blood test showed low serum copper and high serum zinc levels, and it was determined that the patient had copper deficiency due to excess zinc, which was caused by the long-term zinc intake that was prescribed by another department postoperatively. In addition to drug discontinuation, copper supplementation with pure cocoa was administered; subsequently, blood cell counts recovered, and peripheral neuropathy improved. Although zinc replacement therapy is becoming common in patients with cirrhosis, zinc can induce copper deficiency if continuously taken in large doses. Hemopenia due to copper deficiency is frequently difficult to distinguish, and neuropathy may be irreversible. The need to measure serum copper during zinc administration should be communicated.</p>
Journal
-
- Kanzo
-
Kanzo 65 (1), 25-30, 2024-01-01
The Japan Society of Hepatology
- Tweet
Details 詳細情報について
-
- CRID
- 1390580228771685888
-
- NII Book ID
- AN00047770
-
- ISSN
- 18813593
- 04514203
-
- NDL BIB ID
- 033257484
-
- Text Lang
- ja
-
- Data Source
-
- JaLC
- NDL
- Crossref
-
- Abstract License Flag
- Disallowed