Robot-integrated microfluidic chip made by polymers for measuring mechanical properties of cells

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  • 細胞の機械特性計測のための樹脂製ロボット統合型マイクロ流体チップ

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<p>On-chip mechano-indexing has many advantages such as low risk of contamination, stable environment for manipulation, and flow cytometric measurement. In this paper, we propose a microfluidic chip made by rigid polymers; two cyclo-olefin polymer substrates and a polyimide film with force sensor probes. Compared to the conventional robot integrated microfluidic chip composed of glass – silicon – glass layers, the proposed COP – PI – COP chip allow us to reduce the fabrication process with keeping rigidity for the sensor probe. In the experiment, we succeeded in driving a force sensor probe with the fabricated microfluidic chip and measuring the mechano-index of a hydrogel.</p>

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