Monocyte Chemoattractant Protein 1 (MCP-1) Gene Polymorphism Is Not Associated with Severe and Cerebral Malaria in Thailand

DOI NDLデジタルコレクション Web Site Web Site PubMed オープンアクセス
  • Dechkum Naowarut
    Department of Microbiology and Immunology, Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Thailand
  • Hananantachai Hathairad
    Department of Microbiology and Immunology, Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Thailand
  • Patarapotikul Jintana
    Department of Microbiology and Immunology, Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Thailand
  • Ohashi Jun
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Japan
  • Krudsood Srivicha
    Department of Microbiology and Immunology, Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Thailand
  • Looareesuwan Sornchai
    Department of Microbiology and Immunology, Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Thailand
  • Tokunaga Katsushi
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Japan

書誌事項

公開日
2006-08-28
DOI
  • 10.7883/yoken.jjid.2006.239
公開者
国立感染症研究所

この論文をさがす

説明

<p>The pathogenesis of cerebral malaria from Plasmodium falciparum infection is thought to involve inflammation of the central nervous system. Since monocyte chemoattractant protein 1 (MCP-1) is a chemokine strongly involved in the inflammatory process, we here study MCP-1 gene polymorphisms in association with severe or cerebral malaria in Thailand. Malaria patients in the northwest of Thailand were grouped into mild (n = 206), severe (165), and cerebral (110) malaria case groups. Five single nucleotide polymorphisms (SNPs) in the promoter (–2518A/G, –2348G/C, –2158C/T, –2076A/T, and –2072T/C), and 1 SNP in intron 1 (764C/G) were analyzed by PCR-RFLP, PCR-SSP, or direct sequencing. The SNP –2158 was a novel polymorphism found in this study. For all SNPs, genotype and allele frequencies were not significantly different between mild and severe or mild and cerebral malaria. Strong linkage disequilibrium was found among 4 SNPs (–2518A/G, –2348G/C, –2076A/T, and 764C/G), resulting in 4 major estimated haplotypes. The most common haplotype was GGAC. The results indicated that MCP-1 gene polymorphisms were not associated with malaria severity, implying that MCP-1 was not a cause of malaria severity in this Thai population.</p>

収録刊行物

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ