The Emergence of Drug-Resistant Streptococcus pneumoniae and Host Risk Factors for Carriage of Drug-Resistant Genes in Northeastern Japan
-
- Matsumoto Ayumi
- Department of Pediatrics, Fukushima Medical University, Japan
-
- Hosoya Mitsuaki
- Department of Pediatrics, Fukushima Medical University, Japan
-
- Kawasaki Yukihiko
- Department of Pediatrics, Fukushima Medical University, Japan
-
- Katayose Masahiko
- Department of Pediatrics, Soma General Hospital, Japan
-
- Kato Kazuo
- Fukushima Institute of Public Health, Japan
-
- Suzuki Hitoshi
- Department of Pediatrics, Fukushima Medical University, Japan
書誌事項
- タイトル別名
-
- The Emergence of Drug-Resistant <i>Streptococcus pneumoniae</i> and Host Risk Factors for Carriage of Drug-Resistant Genes in Northeastern Japan
- Emergence of Drug Resistant Streptococcus pneumoniae and Host Risk Factors for Carriage of Drug Resistant Genes in Northeastern Japan
この論文をさがす
抄録
<p>Our 2-year study includes research into the occurrence, molecular characteristics, and host risk factors for the carriage of drug-resistant strains of Streptococcus pneumoniae as a continuation of our previous report. From September 2001 to June 2003, strains of S. pneumoniae were isolated from the nasopharynx of children with respiratory tract infection in Soma General Hospital. Of the total of 949 strains, 761 (81%) had a decreased susceptibility to penicillin (MIC > 0.12 μg/ml), while 818 (86%) were resistant to erythromycin (MIC > 1 μg/ml) and 789 (83%) were resistant to clarithromycin (MIC > 1 μg/ml). More than half of the strains had decreased susceptibility to meropenem. Gene analysis of 226 randomly selected strains showed that 200 strains (88.5%) had one or more altered pbp genes and 191 strains (84.5%) had mef(A) and/or erm(B) genes. We reviewed the patient backgrounds for previous antibiotic use, age, daycare attendance, and siblings. Previous use of oral beta-lactams has shown a strong relationship with the carriage of altered pbp genes (P value < 0.01), and previous oral macrolide use has been related to the carriage of macrolide-resistant genes (P value < 0.01). The controlled use of antibiotics might be an important factor in preventing the emergence of S. pneumoniae with antibiotic-resistant genes.</p>
収録刊行物
-
- Japanese Journal of Infectious Diseases
-
Japanese Journal of Infectious Diseases 60 (1), 10-13, 2007-02-28
国立感染症研究所
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390580461190270848
-
- NII論文ID
- 40015274065
-
- NII書誌ID
- AA1132885X
-
- ISSN
- 18842836
- 13446304
- http://id.crossref.org/issn/13446304
-
- NDL書誌ID
- 8656859
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可