Kinetic study of antibodies (IgG, IgA) to Chlamydia trachomatis: importance of IgA antibody in screening test for C. trachomatis infection by peptide-based enzyme immunosorbent assay
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- Komoda Teruko
- Department of Medical Technology, Faculty of Health Sciences, Kyorin University, Japan
書誌事項
- タイトル別名
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- Kinetic Study of Antibodies (IgG, IgA) to <i>Chlamydia trachomatis</i>: Importance of IgA Antibody in Screening Test for <i>C. trachomatis</i> Infection by Peptide-Based Enzyme Immunosorbent Assay
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<p>To assess the importance of only IgA antibody positivity in the peptidebased ELISA (P-ELISA) examination of kinetic behaviors of antibodies (IgA, IgG) to Chlamydia trachomatis, 426 sera from 52 follow-up antigen-positive patients were assayed. In part, a microimmunofluorescence (MIF) test and an immunoblot (IB) assay were also used for confirmation. The results showed that the positivity rates of IgA and IgG antibodies were 82.7 and 96.2%, respectively, at the first testing. One patient had both IgA- and IgG-negative antibodies at the first testing, but this became only IgA-positive and then IgG-positive. The patient was co-infected with Candida albicans and C. trachomatis, and saw a gynecologist for the symptom of itching. Although the major outer membrane protein was negative in IB assay, the results of the MIF test and absorption experiments were positive. MIF titers for IgA and IgG antibodies to C. pneumoniae were <1:8 and 1:32, respectively, at the peak level of P-ELISA. These findings seem to suggest that when only the IgA antibody is detected by P-ELISA, C. trachomatis infection may be present at an early stage, so confirmation via testing for C. trachomatis is needed.</p>
収録刊行物
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- Japanese Journal of Infectious Diseases
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Japanese Journal of Infectious Diseases 60 (6), 347-351, 2007-11-28
国立感染症研究所
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詳細情報 詳細情報について
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- CRID
- 1390580461190403840
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- NII論文ID
- 40015714568
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- NII書誌ID
- AA1132885X
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- ISSN
- 18842836
- 13446304
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- NDL書誌ID
- 9273334
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
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- 抄録ライセンスフラグ
- 使用不可