Hyperpolarized MRI molecular probes for investigation of biological phenomena and pathological diagnosis

DOI
  • Yatabe Hiroyuki
    Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo
  • Sando Shinsuke
    Department of Chemistry and Biotechnology/Department of Bioengineering, Graduate School of Engineering, The University of Tokyo

Bibliographic Information

Other Title
  • 生命現象の理解と病態診断に貢献する超偏極MRI分子プローブ

Abstract

Hyperpolarization techniques dramatically improve the sensitivity of nuclear magnetic resonance imaging (NMR/MRI) molecular probes enabling in vivo detection that is typically difficult with conventional NMR/MRI. Dynamic nuclear polarization (DNP) , one of hyperpolarization techniques, has been applied for real-time monitoring of metabolic reactions and pathological diagnosis through metabolic analysis of highly sensitive molecular probes. For example, [1-13C] pyruvate, a representative DNP-NMR molecular probe, has been utilized for pathological diagnosis of various cancers based on its metabolic rate to [1-13C] lactate. However, there are very few practical DNP-NMR molecular probes, and their design guidelines have not been established. We have developed various DNP-NMR molecular probes through precise molecular design. In this manuscript, we introduce examples of DNP-NMR molecular probes with long hyperpolarization lifetimes and fast enzymatic reactions developed based on relaxation theory and mechanistic insight into molecular recognition.

Journal

  • MEDCHEM NEWS

    MEDCHEM NEWS 34 (1), 25-29, 2024-02-01

    The Pharmaceutical Society of Japan

Keywords

Details 詳細情報について

  • CRID
    1390580472188583552
  • DOI
    10.14894/medchem.34.1_25
  • ISSN
    24328626
    24328618
  • Text Lang
    ja
  • Data Source
    • JaLC
  • Abstract License Flag
    Disallowed

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