Hyperpolarized MRI molecular probes for investigation of biological phenomena and pathological diagnosis
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- Yatabe Hiroyuki
- Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo
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- Sando Shinsuke
- Department of Chemistry and Biotechnology/Department of Bioengineering, Graduate School of Engineering, The University of Tokyo
Bibliographic Information
- Other Title
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- 生命現象の理解と病態診断に貢献する超偏極MRI分子プローブ
Description
Hyperpolarization techniques dramatically improve the sensitivity of nuclear magnetic resonance imaging (NMR/MRI) molecular probes enabling in vivo detection that is typically difficult with conventional NMR/MRI. Dynamic nuclear polarization (DNP) , one of hyperpolarization techniques, has been applied for real-time monitoring of metabolic reactions and pathological diagnosis through metabolic analysis of highly sensitive molecular probes. For example, [1-13C] pyruvate, a representative DNP-NMR molecular probe, has been utilized for pathological diagnosis of various cancers based on its metabolic rate to [1-13C] lactate. However, there are very few practical DNP-NMR molecular probes, and their design guidelines have not been established. We have developed various DNP-NMR molecular probes through precise molecular design. In this manuscript, we introduce examples of DNP-NMR molecular probes with long hyperpolarization lifetimes and fast enzymatic reactions developed based on relaxation theory and mechanistic insight into molecular recognition.
Journal
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- MEDCHEM NEWS
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MEDCHEM NEWS 34 (1), 25-29, 2024-02-01
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390580472188583552
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- ISSN
- 24328626
- 24328618
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- Text Lang
- ja
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- Data Source
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- JaLC
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- Abstract License Flag
- Disallowed