Kidney transplantation for end-stage renal disease after third allogeneic hematopoietic stem cell transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia

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  • NISHIJIMA Akihiko
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
  • SHINGAI Naoki
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
  • OHTA Akihito
    Nephrology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
  • SUDA Kiyoko
    Department of Psycho-oncology/Psychiatry, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
  • OMOTO Kazuya
    Department of Urology, Tokyo Women’s Medical University
  • ISHIDA Shinya
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
  • YOSHIOKA Kosuke
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
  • KUROSAWA Shuhei
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
  • HINO Yutaro
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
  • SENOO Yasushi
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
  • IGARASHI Aiko
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
  • OSHIKAWA Gaku
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
  • HAMAMURA Atsushi
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
  • TOYA Takashi
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
  • SHIMIZU Hiroaki
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
  • NAJIMA Yuho
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
  • KOBAYASHI Takeshi
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
  • HARAGUCHI Kyoko
    Division of Transfusion and Cell Therapy, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
  • OKUYAMA Yoshiki
    Division of Transfusion and Cell Therapy, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
  • OHASHI Kazuteru
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
  • DOKI Noriko
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital

Bibliographic Information

Other Title
  • 3回の同種造血幹細胞移植後の末期腎不全に対し生体腎移植を施行したPhiladelphia染色体陽性急性リンパ芽球性白血病
  • 3カイ ノ ドウシュ ゾウケツ カンサイボウ イショク ゴ ノ マッキ ジンフゼン ニ タイシ セイタイ ジン イショク オ シコウ シタ Philadelphia センショクタイ ヨウセイ キュウセイ リンパ ガキュウセイ ハッケツビョウ

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Abstract

<p>An 18-year-old man underwent allogenic bone marrow transplantation (BMT) for Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL). Ph+ALL relapsed 3 months after the first BMT, and the patient underwent a second BMT. However, Ph+ALL relapsed 4 months after the second BMT, and he received a haploidentical peripheral blood stem cell transplantation (haplo-PBSCT) from his father. Molecular complete remission was confirmed 29 days after haplo-PBSCT. However, the patient needed dialysis for end-stage renal disease due to thrombotic microangiopathy 3 years and 2 months after haplo-PBSCT. He received a kidney transplantation from his father 7 years and 10 months after haplo-PBSCT, and got off dialysis after the kidney transplantation. Immunosuppressive therapy with methylprednisolone, tacrolimus, and mycophenolate mofetil was started for kidney transplantation, but the dose of immunosuppressive agents was reduced successfully without rejection soon after kidney transplantation. The patient has maintained long-term remission since the haplo-PBSCT, and his kidney function was restored by the kidney transplantation from his father.</p>

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 65 (1), 7-12, 2024

    The Japanese Society of Hematology

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