Effect of Hinokitiol on Growth and Biofilm Formation of <i>Streptococcus mutans</i>

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  • YOSHIMATSU Hideki
    Department of Preventive and Community Dentistry, Osaka Dental University
  • KAWAMURA Kahori
    Department of Preventive and Community Dentistry, Osaka Dental University
  • HUANG Zheqi
    Department of Preventive and Community Dentistry, Osaka Dental University Graduate school of Dentistry, Osaka Dental University
  • YANG Shijie
    Department of Preventive and Community Dentistry, Osaka Dental University Graduate school of Dentistry, Osaka Dental University
  • LI Qianying
    Department of Preventive and Community Dentistry, Osaka Dental University Graduate school of Dentistry, Osaka Dental University
  • KITAYAMA Takaya
    Department of Preventive and Community Dentistry, Osaka Dental University Graduate school of Dentistry, Osaka Dental University
  • KOYANAGI Kayo
    Department of Special Care Dentistry, Osaka Dental University Hospital
  • KANO Keita
    Department of Preventive and Community Dentistry, Osaka Dental University
  • DOI Takashi
    Department of Preventive and Community Dentistry, Osaka Dental University
  • ONO Yoshiaki
    Department of Special Care Dentistry, Osaka Dental University Hospital
  • KATAOKA Kosuke
    Department of Preventive and Community Dentistry, Osaka Dental University Department of Oral Health Science and Social Welfare, Graduate School of Biomedical Sciences, Tokushima University
  • MIYAKE Tatsuro
    Department of Preventive and Community Dentistry, Osaka Dental University

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Other Title
  • 天然由来成分ヒノキチオールが<i>Streptococcus mutans</i>の増殖およびバイオフィルム形成に与える影響
  • 天然由来成分ヒノキチオールがStreptococcus mutansの増殖およびバイオフィルム形成に与える影響
  • テンネン ユライ セイブン ヒノキチオール ガ Streptococcus mutans ノ ゾウショク オヨビ バイオフィルム ケイセイ ニ アタエル エイキョウ

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Abstract

<p> Dental caries is the most common disease of the human mouth. Streptococcus mutans is a major cariogenic bacterium. Hinokitiol (HNK), a natural substance extracted from plants such as Chamaecyparis obtusa var., is known for its antibacterial and antifungal properties. Although the antibacterial effect of HNK against periodontal bacteria and fungi has been studied in detail, little is known about its antibacterial effect on cariogenic bacteria, specifically S. mutans. The purpose of this study was to investigate the antibacterial activity of HNK against S. mutans, and evaluate its potential as a preventive agent against cariogenic diseases. HNK marked remarkable antimicrobial activity against cariogenic bacteria. Moreover, it also inhibits the formation of S. mutans biofilms and exhibits bactericidal activity within the biofilms. Furthermore, HNK can inhibit key virulence factors of S. mutans associated with cariogenicity. In conclusion, HNK may be a new agent with anticariogenic potential not solely via inhibition of the growth of cariogenic bacteria.</p>

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