Benign Prostatic Hyperplasia and Incident Cardiovascular Disease

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  • Suzuki Yuta
    Department of Cardiovascular Medicine, The University of Tokyo Center for Outcomes Research and Economic Evaluation for Health, National Institute of Public Health
  • Kaneko Hidehiro
    Department of Cardiovascular Medicine, The University of Tokyo Department of Advanced Cardiology, The University of Tokyo
  • Okada Akira
    Department of Prevention of Diabetes and Lifestyle-Related Diseases, Graduate School of Medicine, The University of Tokyo
  • Fujiu Katsuhito
    Department of Cardiovascular Medicine, The University of Tokyo Department of Advanced Cardiology, The University of Tokyo
  • Jo Taisuke
    Department of Health Services Research, The University of Tokyo
  • Takeda Norifumi
    Department of Cardiovascular Medicine, The University of Tokyo
  • Tanaka Atsushi
    Department of Cardiovascular Medicine, Saga University
  • Node Koichi
    Department of Cardiovascular Medicine, Saga University
  • Morita Hiroyuki
    Department of Cardiovascular Medicine, The University of Tokyo
  • Yasunaga Hideo
    Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo
  • Komuro Issei
    Department of Cardiovascular Medicine, The University of Tokyo International University of Health and Welfare

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抄録

<p>Background: Data regarding the relationship between benign prostatic hyperplasia (BPH) and incident cardiovascular disease (CVD) are scarce. We aimed to clarify the association of BPH with the risk of developing CVD using a nationwide epidemiological database.</p><p>Methods and Results: This retrospective observational cohort study analyzed data from the JMDC Claims Database between 2005 and 2022, including 2,370,986 men (median age 44 years). The primary endpoints were myocardial infarction (MI), angina pectoris (AP), stroke, heart failure (HF), and atrial fibrillation (AF), which were assessed separately. BPH was observed in 48,651 (2.1%) men. During a mean (±SD) follow-up of 1,359±1,020 days, 7,638 MI, 52,167 AP, 25,355 stroke, 58,183 HF, and 16,693 AF events were detected. Hazard ratios of BPH for MI, AP, stroke, HF, and AF were 1.04 (95% confidence interval [CI] 0.92–1.18), 1.31 (95% CI 1.25–1.37), 1.26 (95% CI 1.18–1.33), 1.21 (95% CI 1.16–1.27), and 1.15 (95% CI 1.07–1.24), respectively. We confirmed the robustness of our primary findings through a multitude of sensitivity analyses. In particular, a history of BPH was associated with a higher risk of developing CVD, even in participants without obesity, hypertension, diabetes, or dyslipidemia.</p><p>Conclusions: Our analysis of a nationwide epidemiological dataset demonstrated that BPH was associated with a greater risk of developing CVD in middle-aged men.</p>

収録刊行物

  • Circulation Journal

    Circulation Journal 88 (3), 408-416, 2024-02-22

    一般社団法人 日本循環器学会

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