Investigation of the subchronic effects of low-dose pesticide mixture on rat testes
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- Ömür Ali Doğan
- Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, Atatürk University
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- Sevim Çiğdem
- Department of Medical Pharmacology, Faculty of Medicine, Kastamonu University
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- Sağlam Yavuz Selim
- Department of Pathology, Faculty of Veterinary Medicine, Atatürk University
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- Bolat İsmail
- Department of Pathology, Faculty of Veterinary Medicine, Atatürk University
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- Genç Sıdıka
- Department of Medical Pharmacology, Faculty of Medicine, Bilecik Şeyh Edebali University
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- Yeni Yeşim
- Department of Medical Pharmacology, Faculty of Medicine, Atatürk University
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- Aydın Mehmet Akif
- Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, Kafkas University
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- Sunar Serhat
- Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, Kafkas University
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- Koçak Gökhan
- Organic Agricultural Management Department, Faculty of Applied Sciences, Iğdır University
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- Akarsu Serkan Ali
- Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, Atatürk University
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説明
Pesticides are chemical agents used against living things such as insects, rodents, and weeds that cause toxicity in various tissues, including reproductive organs. In order to increase the effectiveness of pesticides, active ingredients are mixed with various formulations. The current study tried to determine the effects of pesticides and their mixtures on testicular tissue in rats. For this purpose, chlormequat chloride (CCC), pirimiphos methyl (PMM), glyphosate (GLY), tebuconazole (TBZ), chlorpyrifos methyl (CPM), deltamethrin (DLM), and their mix (acceptable daily intake (ADI) and ADIx10) were administried to Sprague-Dawley rats for 90 days. As a result of the examinations, the ADIx10 group showed the most damaging effect by showing a statistical difference in terms of sperm motility and membrane integrity. The GLY group had a similar effect on membrane integrity as the ADIx10 group, while it had a moderately detrimental effect on motility. Degenerations of spermatocytes, necrosis, and edema in intertubular spaces were observed in all pesticide groups. Similarly, 8-hydroxyguanosine (8-OHdG) expression and Caspase-3 expression were moderate in all pesticide groups. Moreover, 8-OHdG expression and Caspase-3 expression were higher in the ADI and ADIx10 groups compared to other groups. As a result, pesticides and their mixtures cause histopathological changes in the testicular tissue of rats and decrease sperm quality.
収録刊行物
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- Japanese Journal of Veterinary Research
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Japanese Journal of Veterinary Research 71 (3), 82-94, 2024-02-27
JJVR編集委員会
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詳細情報 詳細情報について
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- CRID
- 1390580793825529984
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- NII書誌ID
- AA1202891X
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- ISSN
- 2758447X
- 00471917
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- HANDLE
- 2115/91306
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
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- 抄録ライセンスフラグ
- 使用不可