Modulation of Aggregation and Immunogenicity of a Protein: Based on the Study of Hen Lysozyme

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  • Ueda Tadashi
    Graduate School of Pharmaceutical Sciences, Kyushu University

Bibliographic Information

Other Title
  • タンパク質の凝集と免疫原性の調整 —リゾチーム研究を起点として—

Abstract

<p>This study focuses on the modulation of protein aggregation and immunogenicity. As a starting point for investigating long-range interactions within a non-native protein, the effects of perturbing denatured protein states on their aggregation, including the formation of amyloid fibrils, were evaluated. The effects of adducts, sugar modifications, and stabilization on protein aggregation were then examined. We also investigated how protein immunogenicity was affected by enhancing protein conformational stability and other factors.</p>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 144 (3), 299-310, 2024-03-01

    The Pharmaceutical Society of Japan

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