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- Nakayama Yuki
- Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Kajigaya, Japan
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- Sawa Naoki
- Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Kajigaya, Japan
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- Suwabe Tatsuya
- Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Kajigaya, Japan
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- Yamanouchi Masayuki
- Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Kajigaya, Japan
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- Ikuma Daisuke
- Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Kajigaya, Japan
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- Mizuno Hiroki
- Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Kajigaya, Japan
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- Hasegawa Eiko
- Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Kajigaya, Japan
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- Sekine Akinari
- Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Kajigaya, Japan
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- Oba Yuki
- Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Kajigaya, Japan
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- Ishiwata Kazuya
- Department of Hematology, Toranomon Hospital Kajigaya, Japan
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- Wake Atsushi
- Department of Hematology, Toranomon Hospital Kajigaya, Japan
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- Hatano Masaki
- Department of Orthopaedic Surgery, Toranomon Hospital Kajigaya, Japan
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- Kitajima Izuru
- Department of Orthopaedic Surgery, Toranomon Hospital Kajigaya, Japan
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- Kono Kei
- Department of Pathology, Toranomon Hospital Kajigaya, Japan
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- Kinowaki Keiichi
- Department of Pathology, Toranomon Hospital Kajigaya, Japan
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- Takazawa Yutaka
- Department of Pathology, Toranomon Hospital Kajigaya, Japan
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- Takemura Tamiko
- Department of Pathology, Kanagawa Cardiovascular and Respiratory Center, Japan
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- Ubara Yoshifumi
- Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Kajigaya, Japan
抄録
<p>A 58-year-old woman with rheumatoid arthritis was diagnosed with methotrexate-associated Hodgkin lymphoma. After receiving several chemotherapy regimens, she started nivolumab treatment. Two weeks later, she was hospitalized with worsening finger, wrist, and elbow joint pain. A synovial biopsy of the wrist joint showed villous synovial proliferation and linear infiltration of CD68-/CD3-positive T cells (with more CD8 than CD4 T cells) but no CD20-positive B cells or CD138-positive macrophages. These findings corresponded to synovitis associated with immune-related adverse events, which are induced mainly by T cells and are different from typical rheumatoid arthritis (RA), in which B cells play a central role. </p>
収録刊行物
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- Internal Medicine
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Internal Medicine 63 (6), 867-871, 2024-03-15
一般社団法人 日本内科学会