Effect of Two-Photon Excitation to 8-Azacoumarin Derivatives as Photolabile Protecting Groups

  • Kobayakawa Takuya
    Department of Medicinal Chemistry, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU)
  • Takano Hikaru
    Department of Medicinal Chemistry, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU)
  • Ishii Takahiro
    Department of Medicinal Chemistry, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU)
  • Bolah Peter
    Department of Medicinal Chemistry, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU)
  • Tsuji Kohei
    Department of Medicinal Chemistry, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU)
  • Ohashi Nami
    Department of Laboratory of Drug Design and Medicinal Chemistry, Showa Pharmaceutical University
  • Nomura Wataru
    Department of Genome and Biomolecular Engineering for Drug Discovery, School of Pharmaceutical Sciences and Graduate School of Biomedical & Health Sciences, Hiroshima University
  • Furuta Toshiaki
    Department of Biomolecular Science, Faculty of Science, Toho University
  • Tamamura Hirokazu
    Department of Medicinal Chemistry, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU)

抄録

<p>An improvement of the two-photon excitation was achieved using 8-azacoumarin-type caged compounds, which showed large values of the two-photon uncaging action cross-section (δu >0.1 Goeppert–Mayer (GM)). In particular, the 7-hydroxy-6-iodo-8-azacoumarin (8-aza-Ihc)-caged compound showed an excellent uncaging action cross-section value (δu = 1.28 GM). Therefore, 8-azacoumarin-type photolabile protecting groups (PPGs) can be used as two-photon excitation sources.</p>

収録刊行物

参考文献 (20)*注記

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ