Immunostimulatory and Anti-Aging Effects of Sericin Powders Extracted from <i>Antheraea yamamai</i>

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  • Karimazawa Mayumi
    The United Graduate School of Agricultural Sciences, Iwate University Biococoon Laboratories Incorporated
  • Adachi Takahiro
    Department of Precision Health, Medical Research Institute, Tokyo Medical and Dental University
  • Sillapakong Piyamas
    Biococoon Laboratories Incorporated
  • Yamashita Tetsuro
    The United Graduate School of Agricultural Sciences, Iwate University

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  • Immunostimulatory and Anti-Aging Effects of Sericin Powders Extracted from Antheraea yamamai

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<p> We investigated the effect of sericin powder extracted from cocoons of the mulberry silkworm, Bombyx mori, and the non-mulberry silkworm, Antheraea yamamai, on lymphocyte proliferation. Sericin from A. yamamai (AS) elicited significant proliferation of B-lymphocytes. B. mori sericin (BS) and AS extended the lifespan of Caenorhabditis elegans. Transcriptome analysis revealed that AS increased the expression of CD86 and CD69, along with the proinflammatory cytokine IL-1βand the regulatory cytokine IL-10, in mouse spleen cells. The immunostimulatory effect of AS suggests that it has therapeutic value.</p>

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