<p>Lure fishing is a special type of game fishing using artificial fishing lures instead of live baits and has been widely enjoyed around the world. Soft lures with jig heads are a kind of fishing lures that perform vibration behavior by the soft body to attract carnivorous fish. It can be assumed that enhancing their vibration behavior can attract carnivorous fish efficiently. In general, lure design is significantly based on the intuition of the designer and only a few academic works focus on it. In this work, we aim to perform structural design optimization of jig-head soft lures using fluid–structure interaction (FSI) analysis and response surface methodology. At first, we construct the analytical model of a commercial jig-head soft lure for FSI analysis by using a 3D scanner. Then, we perform FSI analysis of the jig-head soft lure using the finite element method (FEM) to reproduce its underwater motion of 3 seconds and obtain the displacements of a designated node in the soft body. According to the results of displacements, we calculate the frequency within the 2s ~ 3s underwater motion using the fast Fourier transform (FFT), and Amount of variation in Y direction. Using the same procedure, we carry out 9 FSI analyses to calculate the frequencies by setting two design variables of the lure, which are the Young’s modulus of the jig head and the length of the soft body. At last, we adopt the results in the central composite design that belongs to the response surface methodology to obtain the optimal the vibration times in 3 seconds, which reaches to its highest value of 11.68.</p>