Development of a Mass Spectrometry Imaging Method to Evaluate the Penetration of Moisturizing Components Coated on Surgical Gloves into Artificial Membranes

  • Nagano Erika
    Research and Development Department, Miruion Corporation
  • Odake Kazuki
    Research and Development Department, Miruion Corporation
  • Akiyoshi Toru
    Marketing Department, Cardinal Health K.K.
  • Shimma Shuichi
    Research and Development Department, Miruion Corporation Department of Biotechnology, Graduate School of Engineering, Osaka University Institute for Open and Transdisciplinary Research Initiatives, Osaka University Osaka University Shimadzu Omics Innovation Research Laboratory, Osaka University

抄録

<p>Skin dryness and irritant contact dermatitis induced by the prolonged use of surgical gloves are issues faced by physicians. To address these concerns, manufacturers have introduced surgical gloves that incorporate a moisturizing component on their inner surface, resulting in documented results showing a reduction in hand dermatitis. However, the spatial distribution of moisturizers applied to surgical gloves within the integument remains unclear. Using matrix-assisted laser desorption/ionization (MALDI)–mass spectrometry imaging (MSI), we investigated the spatial distribution of moisturizers in surgical gloves within artificial membranes. Recently, dermal permeation assessments using three-dimensional models, silicone membranes, and Strat-M have gained attention as alternative approaches to animal testing. Therefore, in this study, we established an in vitro dermal permeation assessment of commercially available moisturizers in surgical gloves using artificial membranes. In this study, we offer a methodology to visualize the infiltration of moisturizers applied to surgical gloves into an artificial membrane using MALDI–MSI, while evaluating commercially available moisturizer-coated surgical gloves. Using our penetration evaluation method, we confirmed the infiltration of the moisturizers into the polyethersulfone 2 and polyolefin layers, which correspond to the epidermis and dermis of the skin, after the use of surgical gloves. The MSI-based method presented herein demonstrated the efficacy of evaluating the permeation of samples containing active ingredients.</p>

収録刊行物

  • Mass Spectrometry

    Mass Spectrometry 13 (1), A0145-A0145, 2024-03-26

    一般社団法人 日本質量分析学会

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