Fluorescent Tryptanthrin Related to Antibacterial and Antifungal Components Extracted from Plant Indigo

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  • KAWAKAMI Jun
    Graduate School of Science and Technology, Hirosaki University

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  • 藍からはじまる蛍光性トリプタンスリン研究

Abstract

<p>Hirosaki University, located in Aomori Prefecture, the northernmost prefecture in Honshu, Japan, began research on tryptanthrin extracted from indigo in 2000, and reported its high antibacterial activity against Malassezia furfur, a causative agent of atopic dermatitis, and its inhibitory effect against contact dermatitis. In the process of synthesizing several tryptanthrin derivatives as antibacterial agents, we accidentally discovered that 2-aminotryptanthrin, in which an amino group was introduced at the 2-position of tryptanthrin, exhibited strong fluorescence, and started new research on tryptanthrin derivatives as fluorescent dyes. Here, we describe the research on fluorescent tryptanthrin derivatives conducted at Hirosaki University.</p>

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