Organic Nanomaterials as Anticancer Agents for Drug Delivery Applications

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  • KOSEKI Yoshitaka
    Institute of Multidisciplinary Research for Advanced Material, Tohoku University
  • KASAI Hitoshi
    Institute of Multidisciplinary Research for Advanced Material, Tohoku University

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  • 有機ナノ材料の抗がん剤としてのドラッグデリバリー応用

Abstract

<p>The development of drug delivery systems (DDS) that allow therapeutic agents to accumulate and exert their effects only at the affected sites is particularly important for the development of drugs that cause severe side effects, such as anticancer drugs. In this review, using SN-38, an anticancer drug, as a model compound, we will discuss the establishment of a method for the preparation of single-molecule nanodrugs using the reprecipitation method, a method for the preparation of organic nanoparticles, the molecular design for controlling the drug release from the nanodrug, and research cases related to the evaluation of pharmacological activity by cell and animal experiments.</p>

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