Bioactivity of human dental pulp-derived stem cells with boron-controlled S-PRG filler eluate by anion exchange

  • TATSUMI Yusuke
    Department of Operative Dentistry, Division of Oral Functional Science and Rehabilitation, Asahi University School of Dentistry
  • KAWAKI Harumi
    Department of Oral Biochemistry, Division of Oral Structure, Function, and Development, Asahi University School of Dentistry
  • SHINTANI Kohei
    Department of Dental Materials Science, Division of Oral Functional Science and Rehabilitation, Asahi University School of Dentistry
  • UENO Kyohei
    Department of Oral Biochemistry, Division of Oral Structure, Function, and Development, Asahi University School of Dentistry
  • HOTTA Masato
    Asahi University
  • KONDOH Nobuo
    Department of Chemistry, Division of Dental Basic Education, Asahi University School of Dentistry
  • BURROW Michael F.
    Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital
  • NIKAIDO Toru
    Department of Operative Dentistry, Division of Oral Functional Science and Rehabilitation, Asahi University School of Dentistry

抄録

<p>Surface pre-reacted glass-ionomer (S-PRG) filler is a bioactive glass filler capable of releasing various ions. A culture medium to which was added an S-PRG filler eluate rich in boron was reported to enhance alkaline phosphatase (ALP) activity in human dental pulp-derived stem cells (hDPSC). To clarify the role of boron eluted from S-PRG fillers, the modified S-PRG filler eluate with different boron concentrations was prepared by using an anion exchange material. Therefore, elemental mapping analysis of anion exchange material, adsorption ratio, hDPSCs proliferation and ALP activity were evaluated. For statistical analysis, Kruskal-Wallis test was used, with statistical significance determined at p<0.05. ALP activity enhancement was not observed in hDPSC cultured in the medium that contained the S-PRG filler eluate from which boron had been removed. The result suggested the possibility that an S-PRG filler eluate with controlled boron release could be useful for the development of novel dental materials.</p>

収録刊行物

  • Dental Materials Journal

    Dental Materials Journal 43 (2), 255-262, 2024-03-25

    一般社団法人 日本歯科理工学会

参考文献 (34)*注記

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ