Evaluation of the Simple Suspension Method for Oral Anticancer Drugs
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- Abe Tomoya
- Department of Pharmacy, Saitama Cancer Center
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- Kusakabe Sanae
- Department of Pharmacy, Saitama Cancer Center
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- Naoi Miho
- Department of Pharmacy, Saitama Cancer Center
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- Suzuki Takayuki
- Department of Pharmacy, Saitama Cancer Center
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- Sagara Atsunobu
- Division of Applied Pharmaceutical Education and Research, Hoshi University School of Pharmacy and Pharmaceutical Sciences
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- Hiraide Makoto
- Division of Applied Pharmaceutical Education and Research, Hoshi University School of Pharmacy and Pharmaceutical Sciences
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- Sano Motohiko
- Division of Applied Pharmaceutical Education and Research, Hoshi University School of Pharmacy and Pharmaceutical Sciences
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- Nakayama Toshiaki
- Department of Pharmacy, Saitama Cancer Center
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Abstract
<p>The simple suspension method (SSM) involves administering tablets or capsules using a tube after disintegration and suspension in hot water without crushing or opening the capsule. Particularly, for anticancer drugs, it is an excellent method of administration that reduces the risk of exposure during dispensing. In contrast, information on SSM for individual drugs is insufficient. Anticancer drugs present a therapeutic challenge because their information is limited. We investigated whether SSM is possible with 36 anticancer drugs. Furthermore, we examined the pH of the suspension of these drugs, for which no information on SSM is available. We found that suspension was possible for 24 of the 36 drugs. Furthermore, the pH of the suspension was measured, which provided important information when considering dissolution solutions other than hot water. Little changes in the pH were observed before or after passing through the tube. The results of this study may improve medication adherence in patients with cancer experiencing dysphagia.</p>
Journal
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- YAKUGAKU ZASSHI
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YAKUGAKU ZASSHI 144 (4), 441-445, 2024-04-01
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390581148795554304
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- NII Book ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL BIB ID
- 033448359
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- PubMed
- 38556318
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
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- Abstract License Flag
- Disallowed