Effect of Enoxaparin and Daikenchuto Coadministration on Hepatic Disorder Markers in Gynecological Cancer Patients after Abdominal Surgery
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- Watanabe Hiroaki
- Department of Pharmacy, Shinshu University Hospital
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- Hirai Keita
- Department of Pharmacy, Shinshu University Hospital Department of Clinical Pharmacology and Therapeutics, Shinshu University Graduate School of Medicine
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- Nakazawa Yuka
- Department of Pharmacy, Shinshu University Hospital
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- Koike Ayaka
- Department of Pharmacy, Shinshu University Hospital
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- Tsuchiya Hiroyuki
- Department of Pharmacy, Shinshu University Hospital
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- Naito Takafumi
- Department of Pharmacy, Shinshu University Hospital Department of Clinical Pharmacology and Therapeutics, Shinshu University Graduate School of Medicine
抄録
<p>Enoxaparin and daikenchuto are commonly administered to prevent venous thromboembolism and intestinal obstruction after gynecological malignancy surgery. However, the effects of their combined use on hepatic function are not well studied. This study aimed to clarify the effects of the coadministration of enoxaparin and daikenchuto on hepatic function. First, Japanese Adverse Drug Event Report (JADER) data were analyzed to identify signals of hepatic disorders. Second, a retrospective observational study of patients who underwent surgery for gynecological malignancies was conducted. This study defined hepatic disorders as an increase in aspartate aminotransferase (AST) or alanine aminotransaminase (ALT) levels above the reference values, using 1-h postoperative values as the baseline. The analysis of JADER data revealed an increased risk for hepatic disorders with the coadministration of enoxaparin and daikenchuto. An observational study also showed higher odds ratios (95% confidence intervals) for the occurrence of hepatic disorders in the coadministration group (4.27; 2.11–8.64) and enoxaparin alone group (2.48; 1.31–4.69) than in the daikenchuto alone group. The median increase in the ALT level was also higher in the coadministration group (34; 15–59) than in the enoxaparin alone (19; 6–38) and daikenchuto alone groups (8; 3–33). In conclusion, our study suggests that compared with the use of enoxaparin or daikenchuto alone, enoxaparin and daikenchuto coadministration increases the risk of hepatic disorders, with more significant increases in AST and ALT levels. Healthcare workers need to be aware of these potential side effects when combining these drugs after surgery for gynecological malignancies.</p>
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 47 (4), 758-763, 2024-04-02
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390581148797123968
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- ISSN
- 13475215
- 09186158
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
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- 抄録ライセンスフラグ
- 使用不可