Prognostic Impact of Serum SCC Antigen in the 566 Upfront Surgery Group of Esophageal Squamous Cell Carcinoma: A Multi-Institutional Study of the Japan Esophageal Society

DOI Web Site PubMed 参考文献16件
  • Suzuki Takashi
    Department of Gastroenterological Surgery and Clinical Oncology, Graduate School of Medicine, Toho University, Tokyo, Japan
  • Yajima Satoshi
    Department of Gastroenterological Surgery and Clinical Oncology, Graduate School of Medicine, Toho University, Tokyo, Japan
  • Okamura Akihiko
    Department of Gastroenterological Surgery, Gastroenterology Center, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan
  • Yoshida Naoya
    Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Kumamoto, Japan
  • Taniyama Yusuke
    Department of Digestive Surgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
  • Murakami Kentaro
    Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Chiba, Japan
  • Ohkura Yu
    Department of Gastroenterological Surgery, Toranomon Hospital, and Okinaka Memorial Institute for Medical Research, Tokyo, Japan
  • Nakajima Yasuaki
    Department of Gastrointestinal Surgery, Tokyo Medical and Dental University, Tokyo, Japan
  • Yagi Koichi
    Department of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
  • Fukuda Takashi
    Department of Gastroenterological Surgery, Saitama Cancer Center Hospital, Kitaadachi-gun, Saitama, Japan
  • Ogawa Ryo
    Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan
  • Hoshino Isamu
    Division of Gastroenterological Surgery, Chiba Cancer Center, Chiba, Chiba, Japan
  • Kunisaki Chikara
    Department of Surgery, Gastroenterological Center, Yokohama City University, Yokohama, Kanagawa, Japan
  • Narumiya Kosuke
    Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan
  • Tsubosa Yasuhiro
    Division of Esophageal Surgery, Shizuoka Cancer Center, Sunto-gun, Shizuoka, Japan
  • Yamada Kazuhiko
    Department of Surgery, National Center for Global Health and Medicine, Tokyo, Japan
  • Shimada Hideaki
    Department of Gastroenterological Surgery and Clinical Oncology, Graduate School of Medicine, Toho University, Tokyo, Japan

説明

<p>Purpose: This study aimed to determine the clinicopathologic and prognostic significance of squamous cell carcinoma antigen (SCC-Ag) in patients with esophageal SCC who underwent radical surgery without neoadjuvant therapy.</p><p>Methods: This study included 566 patients with primary esophageal SCC who underwent radical resection without neoadjuvant therapy at 15 Japanese hospitals between 2008 and 2016. The cutoff value of SCC-Ag was 1.5 ng/mL based on the receiver operating characteristic curves. Preoperative SCC-Ag and postoperative SCC-Ag were analyzed to evaluate clinicopathological and prognostic significance. Survival curves were compared between the SCC-Ag-positive group and the SCC-Ag-negative group. The prognostic impact of SCC-Ag was evaluated using univariate and multivariate analyses.</p><p>Results: The preoperative SCC-Ag-positive rate was 23.5% (133/566). SCC-Ag-positive status was significantly associated with old age (p = 0.042), tumor depth (p <0.001), and tumor stages (p <0.001). The preoperative SCC-Ag-positive group had significantly poorer overall survival than the SCC-Ag-negative group (p = 0.030), but it was not an independent predictor of poor prognosis. Postoperative SCC-Ag-positive status was an independent risk factor for poor overall survival (p = 0.034).</p><p>Conclusion: Both pre- and postoperative SCC-Ag-positive statuses were significantly associated with poor prognosis. Postoperative SCC-Ag-positive status was an independent risk factor for predicting overall survival.</p>

収録刊行物

参考文献 (16)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ